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KAKEN_24592528seika.pdf
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Download
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:290.7 KB
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:Apr 11, 2016 |
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Total downloads since Apr 11, 2016 : 604
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| Title |
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転写因子HOXD9の子宮頸癌における機能解析と新たな治療法の開発
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| Kana |
テンシャ インシ HOXD9 ノ シキュウケイガン ニ オケル キノウ カイセキ ト アラタナ チリョウホウ ノ カイハツ
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Tensha inshi HOXD9 no shikyukeigan ni okeru kino kaiseki to aratana chiryoho no kaihatsu
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Expression and functional analysis of HOXD9 in cervical cancer
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塚崎, 克己
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ツカザキ, カツミ
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Tsukazaki, Katsumi
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慶應義塾大学・医学部・准教授
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Research team head
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科研費研究者番号 : 40118972
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岩田, 卓
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イワタ, タカシ
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Iwata, Takashi
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慶應義塾大学・医学部・専任講師
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Research team member
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科研費研究者番号 : 30296652
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谷口, 智憲
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ヤグチ, トモノリ
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Yaguchi, Tomonori
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 40424163
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河上, 裕
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カワカミ, ユタカ
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Kawakami, Yutaka
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 50161287
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2015
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科学研究費補助金研究成果報告書
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2014
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子宮頸癌における転写因子HOXD9の発現を検討した。子宮頸癌組織においてHOXD9は, 正常子宮頸部組織に比べて高発現しており, 臨床病理学的因子では脈管侵襲およびリンパ節転移と有意に相関した。細胞株を用いた検討では, HOXD9を抑制すると細胞増殖が停止し, 運動能および浸潤能が抑制された。Gene Chip解析ではHOXDの抑制により, 癌抑制遺伝子P53の活性化が生じていることが示唆された。HOXD9は子宮頸癌における新たな治療標的となる可能性がある。
We analyzed the expression and function of HOXD9 in cervical cancers. As a result, HOXD9 gene was overexpressed in cervical cancer tissues than normal cervical tissues. Clinicopathogical analysis using 51 cervical cancer cases revealed HOXD9 expression was associated with lymphovascular space invasion (LVSI) and lymph node metastasis. Silencing of the HOXD9 gene inhibited cell proliferation of cervical cancer cell lines. These results suggested HOXD9 gene is overexpressed in high risk cervical cancer cases and plays important role of cervical cancer cell growth. It has been shown that activation of tumor P53 has occurred by the suppression of HOXD9. HOXD9 is associated with malignant potential in cervical cancer and may be a novel potential target of cervical cancer therapy.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24592528
研究分野 : 子宮頸癌
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