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KAKEN_24592172seika.pdf
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:86.4 KB
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脳腫瘍新生血管を治療標的としたペプチドワクチン療法確立のための効果評価法の開発
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ノウシュヨウ シンセイ ケッカン オ チリョウ ヒョウテキ ト シタ ペプチド ワクチン リョウホウ カクリツ ノ タメ ノ コウカ ヒョウカホウ ノ カイハツ
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Noshuyo shinsei kekkan o chiryo hyoteki to shita pepuchido wakuchin ryoho kakuritsu no tame no koka hyokaho no kaihatsu
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Immune-biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines against malignant glioma patients
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植田, 良
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ウエダ, リョウ
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Ueda, Ryo
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慶應義塾大学・医学部・共同研究員
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Research team head
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科研費研究者番号 : 30317143
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戸田, 正博
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トダ, マサヒロ
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Toda, Masahiro
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慶應義塾大学・医学部・准教授
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Research team member
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科研費研究者番号 : 20217508
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2015
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科学研究費補助金研究成果報告書
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2014
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本研究では, 申請者らが実施している悪性脳腫瘍新生血管を治療標的としたペプチドワクチン療法臨床試験被験者検体を用いて, ①血管新生抑制療法に対する反応性および抵抗性を示す腫瘍血管新生・浸潤性関連因子バイオマーカーや, ②抗腫瘍免疫ネットワークにおける正と負の調節細胞や分子について解析し, 同治療の臨床的有効性との関連性を評価した。同ワクチン療法による臨床的有効性を認めた患者検体では, ワクチン療法後にVEGFR発現細胞反応性細胞傷害性T細胞の高頻度検出, および血清中のsVEGFR2値の低下を認めており, これらは同ワクチン療法バイオマーカーとして治療効果評価や治療反応性予測に応用しうると考えられた。
Immune-biomarkers and -assays are important for development of cancer immunotherapy to monitor immune induction following immunotherapy, and to evaluate anti-tumor effects early after immunotherapy. We characterized status of immune cells, cytokines, chemokines and other immunosuppressive molecules in recurrent malignant glioma patients who received vaccinations of VEGF receptor peptides. Peripheral blood samples from patients who demonstrated positive radiologic response or stable disease revealed superior VEGFR-specific CTL reactivity and lower level of serum VEGF compared to samples from other patients with progressing malignant glioma. These data indicate that these parameters may be potential immune-biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24592172
研究分野 : 脳神経外科学
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