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KAKEN_24591665seika.pdf
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Download
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:166.3 KB
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:Jul 31, 2019 |
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Total downloads since Jul 31, 2019 : 391
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| Title |
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皮膚バリア関連200遺伝子の網羅的解読による新規アトピー性皮膚炎原因遺伝子の同定
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ヒフ バリア カンレン 200 イデンシ ノ モウラテキ カイドク ニ ヨル シンキ アトピーセイ ヒフエン ゲンイン イデンシ ノ ドウテイ
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Hifu baria kanren 200 idenshi no morateki kaidoku ni yoru shinki atopisei hifuen genin idenshi no dotei
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Identification of novel atopic dermatitis candidate genes with sequencing analysis against skin barrier associated 200 genes.
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佐々木, 貴史
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ササキ, タカシ
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Sasaki, Takashi
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 70306843
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久保, 亮治
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クボ, アキハル
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Kubo, Akiharu
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 70335256
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2015
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科学研究費補助金研究成果報告書
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2014
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我々はアトピー性皮膚炎(AD)関連600遺伝子のターゲットリシーケンシング法を確立し日本人AD患者の解読を行った。その結果, 自然免疫もしくは上皮細胞増殖シグナル関連因子を含む6遺伝子変異候補を同定した。その中の1つをAD患者約150人で解析した結果, 顔面及び首周囲に特徴的なパターンの皮疹を形成する集団で高頻度に同定された。現在, 再現性確認のために他集団での解析を行っている。
We established target resequencing method using next generation DNA sequencer for 600 Atopic Dermatitis (AD) related genes, and analyzed against Japanese AD patients. As a result, we isolated 6 candidate AD related mutations including natural immunity and signal pathway in epithelial cells. We analyzed the one candidate mutation against Japanese 150 AD patients among these candidates. Finally, we found the AD patients who show specific dermatitis at face and neck possess this mutation, frequently, and we currently are confirming this result with other Japanese AD patients.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24591665
研究分野 : ゲノム科学
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| Jul 31, 2019 | | 著者,著者版フラグ を変更 |
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