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KAKEN_24590898seika.pdf
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Download
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:241.8 KB
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老化および老年病の発症と末梢血テロメア長の関連についての包括的疫学研究
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ロウカ オヨビ ロウネンビョウ ノ ハツショウ ト マッショウケツ テロメアチョウ ノ カンレン ニ ツイテ ノ ホウカツテキ エキガク ケンキュウ
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Roka oyobi ronenbyo no hatsusho to masshoketsu teromeacho no kanren ni tsuite no hokatsuteki ekigaku kenkyu
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Relatihonship between aging, age-related diseases, and leukocyte telomere length in the oldest old
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新井, 康通
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アライ, ヤスミチ
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Arai, Yasumichi
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 20255467
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広瀬, 信義
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ヒロセ, ノブヨシ
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Hirose, Nobuyoshi
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慶應義塾大学・医学部・特別招聘教授
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Research team member
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科研費研究者番号 : 90142421
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Thomas, von Zglinicki
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Institute of Ageing and Health, Newcastle University
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Research team member
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科研費研究者番号 :
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高山, 美智代
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タカヤマ, ミチヨ
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Takayama, Michiyo
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慶應義塾大学・医学部・特任講師
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Research team member
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科研費研究者番号 : 60265824
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2015
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科学研究費補助金研究成果報告書
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2014
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細胞老化の指標であるテロメア長は加齢とともに短縮し, 心血管死, 感染症死など老化関連疾患と関連する。しかし, これまで健康長寿者におけるテロメア長の報告はきわめて限られていた。本研究では100歳以上の健康長寿者684名, 85-99歳536名, 百寿者の子供とその配偶者167組のテロメア長を測定し, 60-90歳代までは加齢とともにテロメア長が短縮するが, 百歳以降ではテロメアの短縮が起こらず, さらに105歳以上ではテロメアが長い傾向があることを見出した。また, テロメア超は免疫老化の指標であるCD28陽性率と相関した。つまり, テロメア短縮と免疫老化が起こりにくいことが健康長寿者の特徴である可能性を示した。
Leukocyte telomere length (LTL) is an emerging biomarker of aging, and associated with death from cardiovascular and infectious disease. Litte is known about LTL in centenarians. In this study, we measured LTL from 684 centenarians and 167 pairs of their offspring, 536 non-centenarian individual aged between 85-99 years old. we found that LTL actually decreased with age until late 90's, however, centenarians and especially semi-supercentenarians (individuals aged 105 years or older) exhibited longer LTL than expected for their ages. Moreover, centenarians' offspring maintained their LTL compared to non-centenarians. Decrease in percentage of CD28 lymphocyes is known to be associated with age-related decline in immune system (immmunesenescence). Interestingly, LTL in semi-supercentenarians were significantly correlated with CD28(+) lyphocytes. These resluts suggested that maintenance of LTL and immune competence could be hallmark of healthy longevity in humans.
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研究種目 : 基盤研究(C) (一般)
研究期間 : 2012～2014
課題番号 : 24590898
研究分野 : 加齢医学
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