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KAKEN_24590208seika.pdf
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Title |
Title |
プロテオミクスにより見出した新規抗がん剤反応性予測タンパク質のバイオマーカー開発
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プロテオミクス ニ ヨリ ミイダシタ シンキ コウガンザイ ハンノウセイ ヨソク タンパクシツ ノ バイオマーカー カイハツ
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Puroteomikusu ni yori miidashita shinki koganzai hannosei yosoku tanpakushitsu no baiomaka kaihatsu
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Development of new candidate, newly found out by proteomic approach, as a predictive biomarker for chemotherapy
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鈴木, 小夜
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スズキ, サヨ
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Suzuki, Sayo
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慶應義塾大学・薬学部・講師
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Research team head
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科研費研究者番号 : 90424134
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谷川原, 祐介
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タニガワラ, ユウスケ
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Tanigawara, Yusuke
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 30179832
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2015
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科学研究費補助金研究成果報告書
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2014
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抗がん剤治療の個別化には個々の患者の薬剤反応性を治療開始前に見極めるバイオマーカーの確立が必須である。本研究では, 研究代表者が大腸がんにおけるオキサリプラチン感受性予測候補タンパク質として見出した細胞内タンパク質S100A10の機能解析と臨床応用に向けた基礎的検討を行った。その結果, ヒト大腸がん細胞株においてS100A10発現上昇はオキサリプラチン感受性を低下させ, 大腸がん臨床組織検体においてはS100A10発現陰性の場合に比べてS100A10発現陽性である場合に腫瘍縮小効果が低い傾向が認められたことから, S100A10がオキサリプラチン感受性予測タンパク質となる可能性が示された。
Predictive markers for chemotherapeutic response are urgently needed to improve the outcome of cancer treatment. Recently, our proteomics studies have demonstrated that intracellular S100A10 protein expression levels are significantly correlated with the sensitivity of CRC cells to L-OHP, but not 5-FU, providing a new candidate predictive marker for the response to L-OHP. In this study, we have demonstrated that alterations in S100A10 expression is involved in mediating chemosensitivity to L-OHP, by using forced expression of S100A10 in CRC cells, and pilot studies of immunohistochemistry of CRC tissue microarray for S100A10 have suggested that high expression of S100A10 is possibly associated with resistance to L-OHP. These results provide findings for S100A10 as a predictive marker of the response to chemotherapy including L-OHP.
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研究種目 : 基盤研究(C)
研究期間 : 2012~2014
課題番号 : 24590208
研究分野 : 医歯薬学
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