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KAKEN_23791444seika.pdf
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Title |
Title |
周産期出血における子宮動脈NBCA リピオドール塞栓術の基礎研究
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Kana |
シュウサンキ シュッケツ ニ オケル シキュウ ドウミャク NBCA リピオドール ソクセンジュツ ノ キソ ケンキュウ
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Shusanki shukketsu ni okeru shikyu domyaku NBCA ripiodoru sokusenjutsu no kiso kenkyu
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Basic research to embolization uterie artery using NBCA Lipiodol in perinatal bleeding
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細川, 崇洋
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Kana |
ホソカワ, タカヒロ
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Romanization |
Hosokawa, Takahiro
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Affiliation |
慶應義塾大学・医学部・共同研究員
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Research team head
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科研費研究者番号 : 20383854
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井上, 政則
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イノウエ, マサノリ
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Inoue, Masanori
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慶應義塾大学・医学部・共同研究員
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Research team member
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科研費研究者番号 : 30338157
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上野, 彰久
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ウエノ, アキヒサ
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Ueno, Akihisa
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慶應義塾大学・医学研究科・大学院生
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Research team member
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科研費研究者番号 : 80348755
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中塚, 誠之
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Kana |
ナカツカ, セイシ
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Romanization |
Nakatsuka, Seishi
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Affiliation |
慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 50188984
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2014
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科学研究費補助金研究成果報告書
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2013
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Abstract |
周産期出血は母子の生命を脅かす病態である。治療としてNBCAを用いた子宮動脈塞栓術が増えてきたが、塞栓範囲と効果、子宮への障害についての基礎研究は少ない。
まず、豚2匹の子宮動脈をNBCAとリピオドールの混和液を用い塞栓した後、子宮を摘出し、NBCAの分布の範囲を検討した。分解能の高い軟X線を用いた場合、より分布範囲を明瞭に確認することが可能であった。次に、豚2匹の子宮動脈を同様に塞栓した後、2週間飼育した。飼育後、血管造影を行い塞栓物質の残存の程度を塞栓直後と比較した。2週間の間では、子宮動脈内への血管内塞栓物質の残存濃度は異なっていたが、分布の範囲の程度には変化はみられなかった。
Perinatal bleeding is a condition that threatens the life of patient. Now, embolization from the uterine artery has been attempted. And embolization using NBCA has also increased. But there were a few pathological basic research after using NBCA.
First, the uterine artery of two pigs was embolization using lipiodol and NBCA. Hysterectomy was performed to examine the extent of the NBCA and Lipiodol, and to observe in pathologic evaluation. The distribution of embolization material evaluated by soft X-ray was almost concordant by pathological evaluation. Second, after embolization using NBCA, two pigs were fed two weeks. Then angiography was performed to evaluate in the extent of embolic material. Then, we examined pathologically extent of embolic material, the effects on endometrium. In two weeks, it appeared that the degree of residual intravascular embolic material had different concentrations, but not change the extent of the range of distribution.
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研究種目 : 若手研究(B)
研究期間 : 2011~2013
課題番号 : 23791444
研究分野 : 医歯薬学
科研費の分科・細目 : 内科系臨床医学 放射線科学
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