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KAKEN_23591255seika.pdf
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Download
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:214.4 KB
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:Dec 11, 2014 |
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横紋筋細胞を用いた免疫沈降法による自己抗体検索の臨床応用に向けて
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オウモンキン サイボウ オ モチイタ メンエキ チンコウホウ ニ ヨル ジコ コウタイ ケンサク ノ リンショウ オウヨウ ニ ムケテ
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Omonkin saibo o mochiita meneki chinkoho ni yoru jiko kotai kensaku no rinsho oyo ni mukete
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Autoantibodies detection by immunoprecipitaion assay using rhabdomyosarcome cellular extract
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鈴木, 重明
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スズキ, シゲアキ
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Suzuki, Shigeaki
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 50276242
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馬場, 彰泰
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ババ, アキヤス
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Baba, Akiyasu
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北里大学・医学部附属病院・研究員
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Research team member
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科研費研究者番号 : 60296572
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2014
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科学研究費補助金研究成果報告書
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2013
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免疫性筋疾患である重症筋無力症 (MG)と炎症性筋疾患における自己抗体とその臨床的意義について研究を行った。抗体測定の主な手法はアイソトープラベルした横紋筋細胞抽出液蛋白とRNAを抗原とする免疫沈降法である。抗Kv1.4抗体や抗SRP抗体の自己抗体検出は我々研究室の独自の方法である。国内外の多くの施設と共同研究を展開し、臨床的意義を解明した。
抗Kv1.4抗体はMGにおける重篤な合併症である心臓病変、胸腺腫関連MGにおける長期予後などに関連している。また抗SRP抗体陽性ミオパチーの臨床像を解明し、病型分類を提唱した。研究成果は多くの施設から自己抗体測定依頼を受け、臨床現場に還元している。
Anti-signal recognition particle (SRP) antibodies were first found in the serum from a patient with polymyositis and were classified as one of the myositis-specific antibodies. We advocate for clinical recognition of a chronic form of anti-SRP myopathy, usually progressed over one year.
Anti-Kv1.4 antibody was detected by an immunoprecipitation assay using 35S-labeled rhabdomyosarcome cellular extract as the antigen source. Patients with anti-Kv1.4 antibodies showed higher frequencies of thymoma recurrence and MG relapse compared to those without. Anti-Kv1.4 antibody is a useful predictor of the prognosis of thymoma-associated MG. In addition, 70 (10.8%) of 650 MG patients had anti-Kv1.4 antibodies and 60% of them had abnormal ECG findings with high frequencies of T-wave abnormality and QT prolongation. Myocarditis was found in 8 MG patients with anti-Kv1.4 antibodies. Most patients showed rapid deterioration with lethal arrhythmias and severe heart failure.
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研究種目 : 基盤研究(C)
研究期間 : 2011～2013
課題番号 : 23591255
研究分野 : 医歯薬学
科研費の分科・細目 : 内科系臨床医学・神経内科学
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