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KAKEN_22240041seika.pdf
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Download
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:189.0 KB
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| Last updated |
:Dec 11, 2014 |
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Total downloads since Dec 11, 2014 : 400
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| Title |
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中枢神経系における神経細胞社会の構築機構
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チュウスウ シンケイケイ ニ オケル シンケイ サイボウ シャカイ ノ コウチク キコウ
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Chusu shinkeikei ni okeru shinkei saibo shakai no kochiku kiko
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Mechanisms of the development of neuronal cell community in the central nervous system
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仲嶋, 一範
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ナカジマ, カズノリ
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Nakajima, Kazunori
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 90280734
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榊原, 康文
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サカキバラ, ヤスブミ
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Sakakibara, Yasubumi
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慶應義塾大学・理工学部・教授
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Research team member
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科研費研究者番号 : 10287427
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田畑, 秀典
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タバタ, ヒデノリ
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Tabata, Hidenori
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愛知県心身障害者コロニー発達障害研究所・神経制御学部・室長
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Research team member
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科研費研究者番号 : 80301761
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荒巻, 道彦
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アラマキ, ミチヒコ
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Aramaki, Michihiko
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慶應義塾大学・医学部・特任助教
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Research team member
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科研費研究者番号 : 20338099
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2014
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科学研究費補助金研究成果報告書
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2013
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| Abstract |
哺乳類特有の脳構造である大脳皮質脳室下帯/多極性細胞蓄積帯MAZにおいて、それを構成する細胞の産生様式を制御する分子の検索を行い、機能解析や比較ゲノム解析の結果、重要な候補分子を見いだした。さらに、MAZの多極性移動神経細胞に発現する受容体とその内在性リガンドを複数同定するとともに、多極性移動神経細胞の特徴的な動態がPI(3,4)P2-ラメリポディン-Ena/VASP-アクチン系によって制御されることを見いだした。
We have searched for molecules that regulate the patterns of neuronal production in the subventricular zone (SVZ)/multipolar cell accumulation zone (MAZ) of the developing mouse cerebral cortex. As the results of functional assays and comparative genomic analyses, we identified some important candidates that could change the number of proliferative neuronal progenitors in the SVZ. We also have found multiple receptors and ligands that could affect the behavior of multipolar cells in the MAZ. Finally, we show that the behavior of the multipolar cells in the MAZ is controlled through the PI(3,4)P2-Lamellipodin-Ena/VASP-actin system.
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研究種目 : 基盤研究(A)
研究期間 : 2010～2013
課題番号 : 22240041
研究分野 : 総合領域
科研費の分科・細目 : 脳神経科学、神経化学・神経薬理学
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| Apr 27, 2015 | | 概要, フリーキーワード, 抄録, 著者 を変更 |
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