発病前ではあるものの精神病発症のリスクの高い一群が精神病発症危険状態（At Risk Mental State [ARMS]）である。ARMSのうち約30％が精神病（主に統合失調症）に移行するが、"移行者"を正確に早期診断する方法はないため治療の遅れにつながり、予後の悪化につながっていた。本試験では、AMPA受容体の量と分布に基づいて精神病への移行を予測する研究の実行可能性を示した。
At Risk Mental State (ARMS) is a group of individuals who are at high risk of developing psychosis before the onset of illness. People with ARMS often exhibit subtle symptoms such as changes in thinking, mood, and behavior that precede full-blown psychosis. Identifying these individuals early can be crucial for preventive interventions as about 30% of ARMS patients transition to psychosis (mainly schizophrenia). There was no accurate early diagnosis of "transitioners," leading to delays in treatment and worse prognosis. However, current diagnostic methods lack the precision needed to distinguish between those who will develop psychosis and those who will not. This study demonstrates the feasibility of a study to predict transition to psychosis based on the amount and distribution of AMPA receptors. The findings of this study could pave the way for future research into other biomarkers and risk factors associated with the transition to psychosis.

研究種目 : 挑戦的研究 (開拓)
研究期間 : 2020～2023
課題番号 : 20K20603
研究分野 : 精神医学