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KAKEN_19K18914seika.pdf
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Download
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:313.9 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 179
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| Title |
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創傷治癒におけるIL-11/JAK/STAT3 axisを介した新規治療の開拓
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ソウショウ チユ ニ オケル IL-11/JAK/STAT3 axis オ カイシタ シンキ チリョウ ノ カイタク
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Sōshō chiyu ni okeru IL-11/JAK/STAT3 axis o kaishita shinki chiryō no kaitaku
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Development of novel therapies mediated by IL-11/JAK/STAT3 axis in wound healing
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加藤, 達也
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カトウ, タツヤ
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Katō, Tatsuya
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 60641321
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2021
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科学研究費補助金研究成果報告書
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2020
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瘢痕に反復する張力などのメカニカルストレスが加わると瘢痕は肥厚し、患者QOLを著しく低下させる。心筋梗塞後の心臓の線維化にIL11が主要な役割を呈することがわかっており、皮膚瘢痕においてもIL-11の発現が増加することが分かった。メカニカルストレスを負荷することで瘢痕における血管新生が増加し、それにIL11が何らかの影響を与える可能性が示唆された。生体内でのIL-11の影響を確認するためマウスの体内にIL11を投与したが瘢痕には明らかな影響は確認できなかった。さらにケロイド患者由来の瘢痕組織においてもIL11 発現の増加は確認できなかった。
Mechanical stresses such as repetitive tension on the scar can cause scar thickening and significantly reduce patient quality of life. It has been shown that IL11 plays a major role in cardiac fibrosis after myocardial infarction, and IL-11 expression is also increased in skin scars. It was suggested that IL-11 may have some effect on the increase of angiogenesis in scars after mechanical stress. In order to confirm the effect of IL-11 in vivo, they administered IL-11 into the body of mice, but no obvious effect was observed in the scars. Furthermore, no increase in IL11 expression was observed in scar tissue from keloid patients.
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研究種目 : 若手研究
研究期間 : 2019～2020
課題番号 : 19K18914
研究分野 : 形成外科学
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