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KAKEN_18K15094seika.pdf
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Download
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:346.8 KB
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| Last updated |
:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 643
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膵癌組織における免疫抑制性微小環境のデジタル画像解析ならびに亜分類の試み
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スイガン ソシキ ニ オケル メンエキ ヨクセイセイ ビショウ カンキョウ ノ デジタル ガゾウ カイセキ ナラビニ アブンルイ ノ ココロミ
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Suigan soshiki ni okeru men'eki yokuseisei bishō kankyō no dejitaru gazō kaiseki narabini abunrui no kokoromi
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Image analysis-based subtyping of immunosuppressive tumor-immune microenvironment in pancreatic cancer tissue
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眞杉, 洋平
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マスギ, ヨウヘイ
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Masugi, Yōhei
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 90528598
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2020
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科学研究費補助金研究成果報告書
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2019
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| Abstract |
細胞傷害性T細胞 (CD8＋細胞) の組織内密度を定量測定する画像診断技術を開発し、腫瘍中心と辺縁の免疫反応の違いに基づき、200症例以上の膵癌症例について抗腫瘍免疫活性および免疫抑制活性をこれらの指標を数値化する手法を確立した。続いて、これらの指標の臨床病理学的意義を明らかにした。さらに免疫抑制活性と量ならびに空間的に逆相関する免疫抑制因子を検証し、特殊な間質組成をもつ膵がんの一群を見出した。
We established computational quantitative system to calculate tumor-infiltrating CD8+ cells in the tumor center and the tumor margin to establish the quantitative evaluation methods for the anti-tumor immune activity and for the in situ immunosuppressive activity of pancreatic cancer microenvironment. Then, we clarified clinicopathologic significances of these quantitative measurements. We further examined candidate factors/cells contributing to the immunosuppression of pancreatic cancer stroma, and focused on the desmoplastic stroma. Using multiplex immunohistochemistry-based image analyses, we identified a stroma type that showed a significant correlation with aforementioned immunosuppressive activity of pancreatic cancer.
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研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K15094
研究分野 : 人体病理学
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