| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_18K14990seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:435.4 KB
|
| Last updated |
:May 17, 2022 |
| Downloads |
: 248 |
Total downloads since May 17, 2022 : 248
|
|
| Release Date |
|
| Title |
| Title |
薬局・居宅におけるDBS法を用いたPK/PD/PGxに基づく至適個別化療法の確立
|
| Kana |
ヤッキョク・キョタク ニ オケル DBSホウ オ モチイタ PK/PD/PGx ニ モトズク シテキ コベツカ リョウホウ ノ カクリツ
|
| Romanization |
Yakkyoku kyotaku ni okeru DBShō o mochiita PK/PD/PGx ni motozuku shiteki kobetsuka ryōhō no kakuritsu
|
|
| Other Title |
| Title |
The development of optimal individualized therapy based on PK/PD/PGx using the DBS method in community pharmacies and at home
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
横山, 雄太
 |
| Kana |
ヨコヤマ, ユウタ
|
| Romanization |
Yokoyama, Yūta
|
| Affiliation |
慶應義塾大学・薬学部 (芝共立) ・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 70725796
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2021
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2020
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
簡便かつ低侵襲な微量採血によるdried blood spot（DBS）法の活用がTDMおよび遺伝子多型解析の実施において推奨されている。本研究では微量血液を用いるDBS法による薬物濃度測定法および遺伝子多型解析を確立し、DBSカードのK+濃度および赤血球／血漿移行定数を用いる事によるDBS法の全血中濃度から血漿中濃度への換算法の妥当性を明らかとした。今回明らかにしたDBSの全血中濃度から血漿中濃度への換算法の確立は、今後、DBS法を用いたPK/PD/PGxに基づいた有効性および安全性を考慮した個別最適化投与法の構築に繋がる事で薬局・居宅におけるTDM実施に向けても期待できる。
The dried blood spot (DBS) method is recommended for therapeutic drug monitoring (TDM) and genetic polymorphism analyses because the microsampling approach involved is simple and minimally invasive. In the present study, we established a method for measuring drug concentrations and analyzing genetic polymorphisms in a small amount of whole blood using DBS sampling. We also demonstrated the validity of the method to convert whole blood concentrations to plasma concentrations in the DBS method using K+ concentrations on the DBS card and the RBC/plasma rate. The establishment of the method to convert whole blood concentrations to plasma concentrations in DBS will contribute to the development of an individual optimized dosage regimen that considers efficacy and safety based on PK/PD/PGx using DBS, which will facilitate TDM in community pharmacies and at home.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究
研究期間 : 2018～2020
課題番号 : 18K14990
研究分野 : 医療薬学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
