| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_18K14956seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:447.0 KB
|
| Last updated |
:Mar 5, 2021 |
| Downloads |
: 469 |
Total downloads since Mar 5, 2021 : 469
|
|
| Release Date |
|
| Title |
| Title |
グルココルチコイド誘発性糖尿病に対する薬物治療の洗練化と発症予測因子の検討
|
| Kana |
グルココルチコイド ユウハツセイ トウニョウビョウ ニ タイスル ヤクブツ チリョウ ノ センレンカ ト ハッショウ ヨソク インシ ノ ケントウ
|
| Romanization |
Gurukokoruchikoido yūhatsusei tōnyōbyō ni taisuru yakubutsu chiryō no senrenka to hasshō yosoku inshi no kentō
|
|
| Other Title |
| Title |
Optimization of the treatment and investigation of predictors for the glucocorticoid-induced diabetes
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
地引, 綾 (中島, 綾)
 |
| Kana |
ジビキ (ナカジマ), アヤ
|
| Romanization |
Jibiki (Nakajima), Aya
|
| Affiliation |
慶應義塾大学・薬学部 (芝共立) ・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 00746224
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
グルココルチコイド誘発性糖尿病 (GCDM) に対する処方実態調査の結果、GCDMの特徴である食後の血糖上昇の抑制を目的とした薬剤が選択される傾向がみられた。インスリンが処方された患者群では処方されなかった患者群と比べGC投与前から2型糖尿病を合併している患者の割合が有意に高く、GC投与前の血糖の状態が治療薬の選択に影響する可能性が示唆された。また、GC投与患者の11β-HSD1活性測定を行うためにLC-MS/MSを用いた尿中ステロイド濃度測定の条件検討を行った。今後、高用量GCを投与予定の膠原病患者について、GC投与前後の11β-HSD1活性の変化と血糖値の変化の関連について検討する予定である。
We analyzed prescriptions for glucocorticoid (GC) -induced diabetes mellitus (GCDM) and found that drugs tended to be selected for the purpose of suppressing postprandial blood glucose elevation, which is a characteristic of GCDM. Among patients with GCDM, the percentages of patients who were not prescribed insulin was significantly higher in patients with normal blood glucose status than in patients with type 2 diabetes; thus, blood glucose status before GC administration may influence the selection of therapeutic agents.
We also examined the conditions for urinary steroid concentration measurement using LC-MS/MS to calculate 11β-HSD1 activity in GC-treated patients. We plan to investigate the relationship between changes in 11β-HSD1 activity and blood glucose levels before and after GC administration in patients with rheumatic disease who are scheduled to receive a high dose of GC.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K14956
研究分野 : 医療薬学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
