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KAKEN_18K08899seika.pdf
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:589.9 KB
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:Nov 14, 2022 |
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| Title |
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造影剤投与による急性腎障害の機序解明および医薬応用
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| Kana |
ゾウエイザイ トウヨ ニ ヨル キュウセイ ジンショウガイ ノ キジョ カイメイ オヨビ イヤク オウヨウ
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Zōeizai tōyo ni yoru kyūsei jinshōgai no kijo kaimei oyobi iyaku ōyō
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Clarification of the mechanism of acute kidney injury by administration of contrast media and pharmaceutical application
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佐々木, 淳一
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ササキ, ジュンイチ
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Sasaki, Jun'ichi
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 90235250
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本間, 康一郎
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ホンマ, コウイチロウ
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Honma, Kōichirō
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 10383762
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2021
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科学研究費補助金研究成果報告書
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2020
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本研究は造影剤による急性腎障害の進行を抑制する新しい方法を提案することを目的とし、私たちが以前に報告した水素分子に着目した。最初に、水素ガスをラットに吸入させ、組織内溶存水素濃度を高感度水素モニターにて複数臓器で測定した。その結果、水素は拡散単独によって分布しているのではなく血流により強く依存していることが示唆された。その結果を踏まえて、水素含有造影剤を作成し、造影剤腎症モデル動物に対する腎臓保護効果を検討した結果、水素を含まない造影剤を投与した群に比較して腎臓保護作用を示す可能性が示唆された。
Here, we propose a novel method for suppressing the progression of contrast-induced acute kidney injury through the use of hydrogen-containing contrast medium, as we have described previously. Rats were exposed to hydrogen gas by inhalation. A high-sensitivity hydrogen sensor was used to determine the concentration of dissolved hydrogen in multiple organs. Results showed that the distribution of hydrogen was more blood flow-dependent rather than diffusion-dependent. Based on this finding, we prepared a hydrogen-containing contrast medium. A contrast-induced nephropathy animal model was utilized to examine the renoprotective effects of the special medium. The results revealed renoprotective effects on the group treated with hydrogen-containing contrast medium compared to those treated with hydrogen-deficient contrast medium.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K08899
研究分野 : 救急医学
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| May 17, 2022 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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