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KAKEN_18K08581seika.pdf
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心臓移植時ドナー心臓超長時間保存を目指す一酸化炭素を利用した新たな保存法の確立
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シンゾウ イショクジ ドナー シンゾウ チョウチョウジカン ホゾン オ メザス イッサンカ タンソ オ リヨウシタ アラタナ ホゾンホウ ノ カクリツ
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Shinzō ishokuji donā shinzō chōchōjikan hozon o mezasu issanka tanso o riyōshita aratana hozonhō no kakuritsu
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Establishment of a new method using carbon monoxide aiming at long-term preservation of donor heart for heart transplantation
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木村, 成卓
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キムラ, ナリタカ
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Kimura, Naritaka
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 90348657
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大塚, 崇
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オオツカ, タカシ
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Ōtsuka, Takashi
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東京慈恵会医科大学・医学部・教授
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Research team member
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科研費研究者番号 : 40306717
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2021
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科学研究費補助金研究成果報告書
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2020
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本研究では、 人工酸素運搬体である一酸化炭素結合人工赤血球（CO-HbV）を用いて心移植時の虚血再灌流傷害に対する効果を検証した。心移植ラットモデルを用い、心筋保護に際し心筋保護液のみを投与した群とCO-HbV溶液も同時に投与した群の移植心の肉眼的形態および組織像を比較した。HE及びアザン染色において、コントロール群では虚血再灌流傷害に特異的な収縮帯壊死が確認されたが、投与群では心筋細胞の傷害を示すいかなる所見も特に認めなかった。本研究において、心移植の際の心筋保護にCO-HbVを付加することが心筋虚血再灌流傷害の予防に対し有効である可能性が示唆された。
In this study, we examined the effect of carbon monoxide-bound artificial erythrocytes (CO-HbV), which is an artificial oxygen carrier, on ischemia-reperfusion injury during heart transplantation. Using a rat model of heart transplantation, the macroscopic morphology and histology of the donor heart were compared between the group to which only the cardioplegic solution was administered for cardiac arrest and the group to which the CO-HbV solution was also administered at the same time. In HE and Azan staining, contraction band necrosis specific to ischemia-reperfusion injury was confirmed in the control group, but no particular findings indicating cardiomyocyte injury were observed in the administration group. In this study, it was suggested that adding CO-HbV to cardioplegia for donor heart during heart transplantation may be effective in preventing myocardial ischemia-reperfusion injury.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K08581
研究分野 : 心臓血管外科
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