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KAKEN_18K08250seika.pdf
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Download
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:332.4 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 136
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新規転写共役因子LSD1のMR活性制御及び食塩感受性高血圧発症における意義の解明
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シンキ テンシャ キョウヤク インシ LSD1 ノ MR カッセイ セイギョ オヨビ ショクエン カンジュセイ コウケツアツ ハッショウ ニ オケル イギ ノ カイメイ
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Shinki tensha kyōyaku inshi LSD1 no MR kassei seigyo oyobi shokuen kanjusei kōketsuatsu hasshō ni okeru igi no kaimei
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Regulation of MR activity by a novel transcriptional coactivator, LSD1, and its significance in the development of salt-sensitive hypertension
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小林, 佐紀子
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コバヤシ, サキコ
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Kobayashi, Sakiko
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| Affiliation |
慶應義塾大学・医学部 (信濃町) ・特任講師
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Research team head
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科研費研究者番号 : 80383727
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2021
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科学研究費補助金研究成果報告書
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2020
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アルドステロンの短期投与実験で、腎尿細管特異的LSD1ノックアウトマウス（KspLSD1-KO）はENaCαの発現上昇の程度がコントロールマウスに比して有意に強く、アルドステロン感受性の亢進が示唆された。16週齢から42週齢までの長期の高食塩負荷ではKspLSD1-KOではコントロールマウスに比べて有意な血圧上昇が認められ、MR拮抗薬（スピロノラクトン）投与により消失した。両群で強い線維化が認められたがスピロノラクトン投与により通常食と同程度まで抑制された。KspLSD1-KOでは線維化が強い傾向があり、アルドステロン感受性の亢進が示唆された。
In short-term aldosterone administration experiments, renal tubule-specific LSD1 knockout mice (KspLSD1-KO) showed a significantly stronger increase in the expression of ENaCα than control mice, suggesting increased aldosterone sensitivity. KspLSD1-KO mice showed a significant increase in blood pressure compared to control mice, which disappeared after administration of MR antagonist (spironolactone). Strong fibrosis was observed in both groups, but was suppressed by spironolactone to the same extent as in the normal diet; there was a strong tendency toward fibrosis in KspLSD1-KO, suggesting increased aldosterone sensitivity.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K08250
研究分野 : 内分泌内科
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