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KAKEN_18K06758seika.pdf
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:102.3 KB
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:Apr 11, 2024 |
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Total downloads since Apr 11, 2024 : 243
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| Title |
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CYP2Cs及びOATPsを介した薬物-飲食物間相互作用とその個人差の定量的解明
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CYP2Cs オヨビ OATPs オ カイシタ ヤクブツ-インショクブツカン ソウゴ サヨウ ト ソノ コジンサ ノ テイリョウテキ カイメイ
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CYP2Cs oyobi OATPs o kaishita yakubutsu-inshokubutsukan sōgo sayō to sono kojinsa no teiryōteki kaimei
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Analysis of the inter-individual variations of food-drug interactions via CYP2Cs and OATPs
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大谷, 壽一
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オオタニ, ヒサカズ
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Ohtani, Hisakazu
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慶應義塾大学・薬学部 (芝共立) ・教授
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Research team head
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科研費研究者番号 : 70262029
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秋好, 健志
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アキヨシ, タケシ
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Akiyoshi, Takeshi
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Collaborator
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今岡, 鮎子
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イマオカ, アユコ
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Imaoka, Ayuko
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Collaborator
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2021
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科学研究費補助金研究成果報告書
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2020
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薬物-飲食物相互作用の重要な機構として、飲食物成分による薬物代謝酵素や薬物輸送担体の阻害がある。一方で代謝酵素や輸送担体には遺伝的変異の存在が知られている。本研究では、代謝酵素や輸送担体の遺伝子変異が、飲食物成分による阻害の受けやすさに差異をもたらし、このことが薬物-飲食物間相互作用のリスクの個人差要因となっているとの仮説に基づいて検討を進めた。代謝酵素としてはCYP2C9, CYP2C19, 輸送担体としてはOATP1A2, OATP2B1を対象に検討を進めた結果、いずれも遺伝子変異により飲食物成分に対する感受性が異なっていることを明らかにした。また、新規の阻害成分の同定にも成功した。
The mechanism of food-drug interactions includes the inhibition of metabolic enzymes or drug transporters, which have genetic variations. The aim of this study is to clarify whether the genetic variations of metabolic enzymes and transporters lead to the altered inhibitory kinetics of respective inhibitors contained in a variety of fruit juices. We focused upon two metabolic enzymes (CYP2C9 and CYP2C19) and two transporters (OATP1A2 and OATP2B1). Detailed analysis revealed that the inhibitory kinetics of various inhibitors highly differ among genetic variants. Therefore, the genetic variants of metabolic enzymes and drug transporters are considered to be one of the important factors to confer inter-individual variation in the extent of food-drug interactions. We also succeeded in identifying a novel OATP inhibitor, narirutin, from grape fruit juice.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06758
研究分野 : 薬物動態学
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| History |
| May 17, 2022 | | インデックス を変更 |
| Aug 28, 2023 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
| Apr 11, 2024 | | Creator を変更 |
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