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KAKEN_18K06734seika.pdf
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| Title |
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フラボノイド混合物の抗炎症作用メカニズムの解析とその応用
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フラボノイド コンゴウブツ ノ コウエンショウ サヨウ メカニズム ノ カイセキ ト ソノ オウヨウ
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Furabonoido kongōbutsu no kōenshō sayō mekanizumu no kaiseki to sono ōyō
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Mechanistic study of anti-inflammatory activity of flavonoid mixtures and its application
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木内, 文之
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キウチ, フミユキ
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Kiuchi, Fumiyuki
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慶應義塾大学・薬学部 (芝共立) ・教授
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Research team head
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科研費研究者番号 : 60161402
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植草, 義徳
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ウエクサ, ヨシノリ
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Uekusa, Yoshinori
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慶應義塾大学・薬学部 (芝共立) ・助教
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Research team member
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科研費研究者番号 : 30753024
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2021
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科学研究費補助金研究成果報告書
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2020
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生薬オウゴンに含まれるbaicalein (1), wogonin (2), oroxylin A (3), 6-methoxywogonin (4)の４種のフラボノイドの等量混合物の抗炎症作用を、培養細胞に対するリポポリ多糖刺激によるプロスタグランジンE2 (PGE2)並びに一酸化窒素(NO)産生抑制を用いて解析し、1～3の混合物 (3mix)は個々の化合物の作用の和より強力（相乗的）にPGE2産生を抑制し、これに4を加えても作用の増強が見られなかった。一方、NO産生では3mixに相乗作用は見られなかったものの、これに4を加えると相乗的に効果が増強されることを明らかにした。
Anti-inflammatory effect of an equimolar mixture of four flavonoids, baicalein (1), wogonin (2), oroxylin A (3), 6-methoxywogonin (4) contained in Scutellaria root, was analyzed using inhibition of the lipopolysaccharide-induced production of prostaglandin E2 (PGE2) and nitric oxide (NO) in cultured cells. A mixture of 1～3 (3-mix) inhibited the production of PGE2 stronger (synergistic effect) than that of a sum of each compound and addition of 4 to the 3-mix did not enhance the activity. On the contrary, the 3-mix did not show synergism in the inhibition of NO production, but addition of 4 exserted synergistic effect.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06734
研究分野 : 生薬学・天然物化学
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| May 17, 2022 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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