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KAKEN_17K19613seika.pdf
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Download
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:317.7 KB
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:Oct 31, 2019 |
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: 500 |
Total downloads since Oct 31, 2019 : 500
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卵巣癌DNAコピー数異常の謎を解く : piRNAの卵巣癌への関与
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ランソウガン DNA コピースウ イジョウ ノ ナゾ オ トク : piRNA ノ ランソウガン エノ カンヨ
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Ransōgan DNA kopīsū ijō no nazo o toku : piRNA no ransōgan eno kan'yo
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Elucidating the mechanisms of DNA copy number aberrations in ovarian cancer : role of piRNA in ovarian cancer
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千代田, 達幸
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チヨダ, タツユキ
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Chiyoda, Tatsuyuki
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慶應義塾大学・医学部 (信濃町)・助教
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Research team head
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科研費研究者番号 : 40445367
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佐藤, 薫
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サトウ, カオル
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Satō, Kaoru
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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Piwi-interacting RNA (piRNA)は生殖組織特異的に産生される小分子RNA群である。卵巣漿液性癌5検体と正常卵巣2検体を用いて全トランスクリプトーム解析 (mRNA-seq) および全小分子RNA解析 (miRNA-seq) を行ったところ、20-23塩基長のmiRNAは卵巣癌と正常卵巣の間で発現パターンが明らかに異なっていたが、26-34塩基長のpiRNAは卵巣癌の一部において発現異常がおきていた。統合的解析により26個のmRNA-small RNAネットワークが明らかとなり、piRNA-RPS6KL1ネットワークの解析ではRPS6KL1の高発現群は有期に予後が悪かった。
Piwi-interacting RNA (piRNAs) are animal-specific small RNAs usually restricted to the germline, which act on transposon silencing. We performed whole transcriptome sequencing (mRNA-seq) and whole small RNA sequencing (miRNA-seq) using 5 serous ovarian cancers and 2 normal ovaries. miRNA-seq showed that 20-23 nt miRNA profiles differ greatly among ovarian cancers and normal ovaries. 26-34 nt piRNA profiles differ in some ovarian cancers. Integrative analysis of mRNA-seq and miRNA-seq revealed 26 ovarian cancer specific mRNA-small RNA networks. Among them, high expression of RPS6KL1 was correlated with worse survival in ovarian cancer.
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研究種目 : 挑戦的研究(萌芽)
研究期間 : 2017～2018
課題番号 : 17K19613
研究分野 : 婦人科腫瘍学
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