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KAKEN_17K14942seika.pdf
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Title |
Title |
領野間情報伝達を担う投射先選択的な神経細胞間の同期発火
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Kana |
リョウヤカン ジョウホウ デンタツ オ ニナウ トウシャサキ センタクテキ ナ シンケイ サイボウカン ノ ドウキ ハッカ
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Ryōyakan jōhō dentatsu o ninau tōshasaki sentakuteki na shinkei saibōkan no dōki hakka
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Synchronous firing between target-selective neurons responsible for inter-cortical communication
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石川, 理子
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イシカワ, アヤコ
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Ishikawa, Ayako
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慶應義塾大学・医学部 (信濃町) ・特任助教
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Research team head
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科研費研究者番号 : 60547991
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2020
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科学研究費補助金研究成果報告書
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2019
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生後発達期の脳は周囲の環境からの感覚入力パターンに応じて大きく脳内ネットワークを柔軟に変化させる。本研究成果は、大脳皮質一次視覚野には、異なる柔軟性を持つ神経ネットワークが存在することを示した。大脳皮質において、浅層と深層の神経細胞間の同期発火の形成に必要な視覚環境が異なった。浅層 (2-4層) では、類似した視覚反応性をもつ神経細胞間で同期的な神経活動が生じ、この同期発火は視覚環境に依存し形成された。一方、深層 (5/6層) では、同期発火の視覚選択性は弱く、その形成は生後発達期における視覚環境に対する依存度が2/3層より低かった。
During postnatal development, neural circuit in the cerebral cortex flexibly changes in response to sensory input patterns from the surrounding environment. We have shown that two neural circuits with different flexibility were embedding in the primary visual cortex. The visual environment required for the formation of synchronous firing was different depending on the layer. In the upper layers (layers 2-4), synchronous firing occurred between neurons with similar visual selectivity, and this synchronous firing was formed in a visual environment-dependent manner. In contrast, in the lower layers (5/6 layers), synchronous firing occurred neuron with distinct visual selectivity and its formation was less dependent on the visual environment during postnatal development than in the upper layers.
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研究種目 : 若手研究 (B)
研究期間 : 2017~2019
課題番号 : 17K14942
研究分野 : 神経科学
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