| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_17K13228seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:191.4 KB
|
| Last updated |
:Oct 31, 2019 |
| Downloads |
: 827 |
Total downloads since Oct 31, 2019 : 827
|
|
| Release Date |
|
| Title |
| Title |
エピゲノムによる老化制御機構の解明と筋再生モデル
|
| Kana |
エピゲノム ニ ヨル ロウカ セイギョ キコウ ノ カイメイ ト キン サイセイ モデル
|
| Romanization |
Epigenomu ni yoru rōka seigyo kikō no kaimei to kin saisei moderu
|
|
| Other Title |
| Title |
A molecular mechanism of aging through epigenome and muscle regeneration
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
早野, 元詞
 |
| Kana |
ハヤノ, モトシ
|
| Romanization |
Hayano, Motoshi
|
| Affiliation |
慶應義塾大学・医学部 (信濃町)・特任講師
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 30593644
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2019
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2018
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
DNA損傷によるエピゲノム変化と老化誘導が可能なICE (Induced Changes in Epigenome) マウスでは３週間のDNA損傷誘導によって老化が加速され、筋力が低下する。網羅的遺伝子解析によ ってRPS28, RPS24などリボソーム遺伝子、ATP5k, Ndufa8, COX8などOXPHOS遺伝子、筋肉ミオシン遺伝子である Myh7, Myh9遺伝子などが変化している。またこれらの遺伝子領域におけるH3K4me1やH4K20me1のヒストン修飾がICEマウス筋肉組織において変化しており、LSD1やSETD8といったエピゲノム因子の関与と筋組織機能制御の可能性が示されている。
ICE (Induced changes in epigenome) mice is a novel mouse model in which aging related phenotypes and the changes in epigenome are induced by DNA damage through I-PpoI endonuclease. By induction of DNA damage for three weeks at 4 to 6 months age in mice, muscle mass and muscle functions are declined at 10 months post-treatment. Transcriptome analysis with RNA-seq showed ribosomal genes (RPS28 and RPS 24), OXPHOS genes (ATP5k, Ndufa8, COX8) and myosin-related genes (Myh7, Myh9) are altered at 10 month after induction of aging along with changes in H3K4me1 and H4K20me1 at those genes in ICE mice. Those data indicate that LSD1 and SETD8 invloved in regulation of aging and muscle function during aging.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究(B)
研究期間 : 2017～2018
課題番号 : 17K13228
研究分野 : 老化
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
