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KAKEN_17K10492seika.pdf
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Title |
Title |
低線量照射における放射線超感受性を用いた低侵襲がん治療戦略の開発 : 膠芽腫での検討
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Kana |
テイセンリョウ ショウシャ ニ オケル ホウシャセン チョウカンジュセイ オ モチイタ テイシンシュウ ガン チリョウ センリャク ノ カイハツ : コウガシュ デノ ケントウ
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Teisenryō shōsha ni okeru hōshasen chōkanjusei o mochiita teishinshū gan chiryō senryaku no kaihatsu : kōgashu deno kentō
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Minimally invasive cancer treatment strategy using hyper-radiosensitivity in low-dose repeat irradiation : a glioblastoma study
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深田, 淳一
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フカダ, ジュンイチ
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Fukada, Jun'ichi
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 50338159
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公田, 龍一
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コウタ, リュウイチ
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Kōta, Ryūichi
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team member
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科研費研究者番号 : 00464834
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小池, 直義
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コイケ, ナオヨシ
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Koike, Naoyoshi
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team member
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科研費研究者番号 : 60464913
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2020
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科学研究費補助金研究成果報告書
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2019
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Abstract |
難治性の悪性腫瘍である膠芽腫に対する治療法として低線量照射における放射線超感受性に着眼した。膠芽腫細胞に対する低線量照射のインターバルとして30分間隔が反応良好であった。その原因として照射後の細胞周期を経時的に観察したところ、約5時間程度で変化が著明であった。反復照射中に放射線感受性の高い細胞周期への移動を生じていることが反応良好である理由であり、反復照射が有効な治療法と結論付けた。
We focused on hyper-radiosensitivity at low dose irradiation as a treatment for glioblastoma, a refractory malignant tumor. Thirty-minute intervals showed a good response for a low-dose irradiation interval compared to other shorter intervals in several malignant glioma cell lines. We performed cell cycle observation after irradiation at several time course. The change was not significant in 30 minutes and 3hours but remarkable in about 5 hours. The most prominent foci fluorescence due to DBA damage repair was observed in the cells collected 30 minutes after irradiation but the difference in foci number between single and repeated irradiation was unclear. It was difficult to sort M-phase cells by the shake-off method. The cell ratio of M phase by irradiation was measured by immunostaining. We conclude that repeated irradiation is an effective treatment because the reaction is good because it causes migration to the cell cycle that is radiosensitive during repeated irradiation.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017~2019
課題番号 : 17K10492
研究分野 : 放射線治療
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Mar 5, 2021 | | インデックス を変更 |
Nov 15, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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