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KAKEN_17K08769seika.pdf
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:246.6 KB
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:Mar 18, 2022 |
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Total downloads since Mar 18, 2022 : 253
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胆道がんの臨床病理学的特徴を規定する遺伝子発現・異常の同定と診断・治療への応用
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タンドウガン ノ リンショウ ビョウリガクテキ トクチョウ オ キテイスル イデンシ ハツゲン・イジョウ ノ ドウテイ ト シンダン・チリョウ エノ オウヨウ
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Tandōgan no rinshō byōrigakuteki tokuchō o kiteisuru idenshi hatsugen ijō no dōtei to shindan chiryō eno ōyō
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Identification of gene expression and abnormalities that define clinicopathological features of biliary tract carcinoma and their application in diagnosis and treatment
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尾島, 英知
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オジマ, ヒデノリ
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Ojima, Hidenori
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慶應義塾大学・医学部 (信濃町) ・准教授
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Research team head
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科研費研究者番号 : 80342905
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2020
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科学研究費補助金研究成果報告書
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2019
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予後良好で特徴的な組織形態像を示す細胆管細胞癌(CoCC)に注目して、その分子病理学的意義を検討した。肝内胆管癌(CCC)のCoCC成分の有無による遺伝子発現の差異をGene Set Enrichment Analysis、遺伝子異常をWhole exome sequenceデーターベースを用いて解析した。その結果、CoCC成分を有するCCCは予後良好・炎症反応・血管新生に関連する遺伝子群と優位に相関し、代表的なTP53をはじめとする癌関連遺伝子の遺伝子異常が有意に低く、臨床病理学的所見と合致した。
We investigated the molecular pathological significance of cholangiolocellular carcinoma (CoCC). We analyzed the differences in gene expression of cholangiocellular carcinoma (CCC), with and without CoCC, using gene set enrichment analysis as well as gene abnormalities using a whole-exome sequence database. Thus, a group of CCC with CoCC, in comparison with CCC without CoCC, was found to be significantly associated with genes involved in favorable prognosis, inflammatory response, and angiogenesis; in contrast, the gene abnormalities of cancer-related genes, such as the typical TP53, were significantly low. These results are consistent with the clinicopathological feature of CoCC.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K08769
研究分野 : 病理学
PDFファイルは改訂版に差し替え (2022.3.15)
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| Mar 5, 2021 | | インデックス を変更 |
| Mar 15, 2022 | | Preview,Full text,Abstract 内容,Note 注記 を変更 |
| Mar 18, 2022 | | Note 注記 を変更 |
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