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KAKEN_17H07089seika.pdf
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Download
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:767.7 KB
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:Aug 28, 2023 |
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Total downloads since Aug 28, 2023 : 802
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肝細胞癌における免疫微小環境の網羅的解析
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カンサイボウガン ニ オケル メンエキ ビショウ カンキョウ ノ モウラテキ カイセキ
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Kansaibōgan ni okeru men'eki bishō kankyō no mōrateki kaiseki
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Comprehensive analysis of immune microenvironment in hepatocellular carcinoma (HCC)
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紅林, 泰
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クレバヤシ, ユタカ
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Kurebayashi, Yutaka
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| Affiliation |
慶應義塾大学・医学部 (信濃町)・助教
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Research team head
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科研費研究者番号 : 40805123
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2019
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科学研究費補助金研究成果報告書
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2018
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肝細胞癌の免疫微小環境を検討するため、肝細胞癌切除検体の標本上において様々な種類の免疫細胞を染め分け (多重免疫染色)、顕微鏡を用いて各免疫細胞の数と分布を詳細に検討した。統計学的に解析した結果、肝細胞癌における免疫微小環境は３つのパターンに分類されることがわかった。このうち Immune-highパターンとした一群はT細胞とB細胞・形質細胞の共浸潤に特徴付けられ、このような免疫微小環境を呈する肝細胞癌は術後の再発率が有意に低かった。また、肝細胞癌が多段階発癌の良いモデルであることを用いて、肝細胞癌の多段階発癌の過程で免疫微小環境も段階的に変化することを示した。
To analyze the patterns of anti-tumor immunity against hepatocellular carcinoma (HCC), we performed multi-color immunohistochemistry to histopathologically evaluate various immune cells and analyzed the number and distribution of each type of immune cells using microscopy. Consequently, we revealed that the patterns of anti-tumor immunity against HCC can be classified into 3 patterns, among which "Immune-high pattern" was characterized by the co-infiltration of T cells and B/plasma cells and significantly associated with better prognosis after surgical resection of HCC. We also revealed how the pattern of anti-tumor immunity changes during the course of multi-step carcinogenesis of HCC.
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研究種目 : 研究活動スタート支援
研究期間 : 2017～2018
課題番号 : 17H07089
研究分野 : 人体病理学
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| Oct 31, 2019 | | インデックス を変更 |
| Aug 28, 2023 | | Creator,Abstract 内容,Note 注記 を変更 |
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