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KAKEN_17H04353seika.pdf
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Download
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:118.6 KB
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:Nov 14, 2022 |
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Total downloads since Nov 14, 2022 : 333
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| Title |
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Sirtuinを標的とした眼疾患の新しい予防、治療方法の開発
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| Kana |
Sirtuin オ ヒョウテキ ト シタ ガンシッカン ノ アタラシイ ヨボウ、チリョウ ホウホウ ノ カイハツ
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Sirtuin o hyōteki to shita ganshikkan no atarashii yobō, chiryō hōhō no kaihatsu
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A novel prevention and treatment method of ocular aging by targeting sirtuins
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坪田, 一男
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ツボタ, カズオ
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Tsubota, Kazuo
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 40163878
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川島, 素子
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カワシマ, モトコ
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Kawashima, Motoko
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慶應義塾大学・医学部 (信濃町) ・特任講師
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Research team member
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科研費研究者番号 : 00327610
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稲垣, 絵海
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イナガキ, エミ
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Inagaki, Emi
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慶應義塾大学・医学部 (信濃町) ・特任助教
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Research team member
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科研費研究者番号 : 40464903
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栗原, 俊英
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クリハラ, トシヒデ
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Kurihara, Toshihide
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慶應義塾大学・医学部 (信濃町) ・特任准教授
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Research team member
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科研費研究者番号 : 50365342
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2020
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科学研究費補助金研究成果報告書
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2019
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長寿遺伝子Sirtuinを標的として新しい眼疾患の予防法を構築することを目的として研究を行った。Sirtuinの活性化に関連する分子NADに着目LC-MS/MSを用いた高感度NAD関連代謝産物の計測系を用い生体内濃度を計測した。In vitro、in vivoの前眼部・後眼部の眼疾患モデルでNAD関連の中間代謝産物による治療効果の検証を行い、有用な結果を得た。さらにNMNの単回投与の安全性をヒトでの臨床研究によって実証した。これらの結果はNAD関連代謝産物の補完によるSirtuinの活性化が眼疾患の予防の一助になりうる可能性を示唆している。
In this study, we aimed to develop a new innovative prevention method for ocular diseases by targeting sirtuins. We established the measurement of nicotinamide adenine dinucleotide (NAD)-related metabolites which are known to activate sirtuins and measured the concentration of these NAD-related metabolites in the aqueous humor, plasma and cerebrospinal fluid. We investigated the anti-oxidative and anti-apoptotic effects of these NAD-related metabolites and obtained promising results in an anterior and posterior disease model both-in vitro and in vivo. Furthermore, we performed a clinical trial to confirm its safety in human by oral administration of Nicotinamide Mononucleotide (NMN) which can directly be converted to NAD. These results suggest that activation of sirtuins by administration of NAD-related metabolites could be a possible treatment for ocular aging diseases.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2017～2019
課題番号 : 17H04353
研究分野 : 抗加齢医学、眼科学
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| History |
| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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