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KAKEN_17H04318seika.pdf
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Download
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:185.7 KB
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:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 275
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脊髄損傷後の神経幹細胞移植に対する免疫抑制剤の効果 : C5aアンタゴニストの有用性
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セキズイ ソンショウゴ ノ シンケイ カンサイボウ イショク ニ タイスル メンエキ ヨクセイザイ ノ コウカ : C5a アンタゴニスト ノ ユウヨウセイ
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Sekizui sonshōgo no shinkei kansaibō ishoku ni taisuru men'eki yokuseizai no kōka : C5a antagonisuto no yūyōsei
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Efficacy of C5a antagonist for human iPS-derived neural precursor cells transplanted into injured spinal cord
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名越, 慈人
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ナゴシ, ナリヒト
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Nagoshi, Narihito
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 10383837
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2020
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科学研究費補助金研究成果報告書
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2019
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脊髄損傷の急性期では炎症反応が強く、神経幹細胞の移植を行っても生着せず、効果が期待できない。本研究では、炎症反応を惹起する補体の抑制剤を投与することで、急性期にヒトiPS細胞由来神経幹細胞を移植したところ、細胞の生着率が向上し、運動機能の回復も認めた。補体抑制剤を用いることで、急性期の炎症性サイトカインの発現や炎症細胞の浸潤、さらには宿主の神経細胞のアポトーシスも抑制されており、移植細胞にとって良好な環境が整っていることが考えられた。
Because inflammatory reaction is intense at acute phase of spinal cord injury (SCI), cell transplantation therapy during this stage is not effective due to low survival rate of transplanted cells. In this study, by administrating complement receptor antagonist, transplanted human iPS cell-derived neural stem cells well survived and promoted motor functional recovery when grafted even at acute phase. The antagonist suppressed the expression of inflammatory cytokines, infiltration of inflammatory cells, and the apoptosis of neural cells in the spinal cord. This histological efficacy can contribute to making a favorable environment for the transplanted cells to survive. We believe that this study will lead to future clinical application as a treatment that enhances the effect of cell transplantation for SCI.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2017～2019
課題番号 : 17H04318
研究分野 : 脊髄損傷
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