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KAKEN_17H04232seika.pdf
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Download
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:388.9 KB
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| Last updated |
:Nov 14, 2022 |
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: 322 |
Total downloads since Nov 14, 2022 : 322
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胎児脳・未熟脳における星状グリアの産生メカニズムの解明と治療応用にむけた機能解析
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タイジ ノウ・ミジュク ノウ ニ オケル セイジョウ グリア ノ サンセイ メカニズム ノ カイメイ ト チリョウ オウヨウ ニ ムケタ キノウ カイセキ
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Taiji nō mijuku nō ni okeru seijō guria no sansei mekanizumu no kaimei to chiryō ōyō ni muketa kinō kaiseki
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Mechanisms underlying gliogenesis of astrocytes in premature brain
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高橋, 孝雄
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タカハシ, タカオ
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Takahashi, Takao
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 80171495
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三橋, 隆行
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ミツハシ, タカユキ
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Mitsuhashi, Takayuki
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 80338110
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芝田, 晋介
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シバタ, シンスケ
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Shibata, Shinsuke
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 70407089
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武内, 俊樹
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タケノウチ, トシキ
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Takenouchi, Toshiki
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 60383741
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2020
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科学研究費補助金研究成果報告書
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2019
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本研究では、これまでに定量解析されていなかった星状グリアの大脳皮質構築異常に果たす役割を検討したうえで、未熟脳の脳障害に星状グリアが果たす役割の解明を目指し実施した。ヒストン脱アセチル化酵素阻害作用を持つ抗てんかん薬バルプロ酸 (VPA) を胎内曝露することで大脳皮質内の星状グリア数が増加し、エピジェネティックな遺伝子発現異常が生後の星状グリア内においても継続して観察される点を明らかにした。
Recent reports have shown that the astrocyte have multiple roles in maintaining structure of neocortices and behavioral brain functions in mammals. The goal of this analysis was to investigate the role of astrocyte in neocortical histogenesis. We show here that in utero exposure of histone deacetylase inhibitor valproate (VPA) increased the number of astrocyte in neocortices in young adult mice. In addition, specific genes that were critical for ADP biosynthetic process were increased in the neocortical astrocytes by VPA exposure in utero.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2017～2019
課題番号 : 17H04232
研究分野 : 医歯薬学
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| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Creator 著者ID,Abstract 内容,Note 注記 を変更 |
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