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KAKEN_17H02103seika.pdf
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Title |
Title |
新規のヒト由来膜透過促進ペプチドを利用したバイオ医薬の細胞選択的DDSの開発
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シンキ ノ ヒト ユライマク トウカ ソクシン ペプチド オ リヨウシタ バイオ イヤク ノ サイボウ センタクテキ DDS ノ カイハツ
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Shinki no hito yuraimaku tōka sokushin pepuchido o riyōshita baio iyaku no saibō sentakuteki DDS no kaihatsu
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Title |
Development of cell-specific DDS for biopharmaceuticals using a novel human-derived membrane penetration-enhancing peptide
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土居, 信英
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Kana |
ドイ, ノブヒデ
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Romanization |
Doi, Nobuhide
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Affiliation |
慶應義塾大学・理工学部 (矢上) ・教授
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Research team head
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科研費研究者番号 : 50327673
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藤原, 慶
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Kana |
フジワラ, ケイ
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Romanization |
Fujiwara, Kei
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慶應義塾大学・理工学部 (矢上) ・講師
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Research team member
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科研費研究者番号 : 20580989
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岩城, 洸汰
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イワキ, コウタ
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Iwaki, Kōta
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Collaborator
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漆島, 穣一
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ウルシマ, ジョウイチ
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Urushima, Jōichi
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菊地, 萌希
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キクチ, モエキ
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Kikuchi, Moeki
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鈴木, 麻友子
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スズキ, マユコ
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Suzuki, Mayuko
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Collaborator
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前村, 帆南
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マエムラ, ホナミ
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Maemura,Honami
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Collaborator
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中村, 桃子
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ナカムラ, モモコ
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Nakamura, Momoko
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Collaborator
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井本, 正哉
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イモト, マサヤ
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Imoto, Masaya
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2020
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科学研究費補助金研究成果報告書
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2019
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Abstract |
標的分子に対して高い特異性と親和性をもつ抗体/ペプチド/核酸などのバイオ医薬は、従来の低分子化合物医薬と比べて副作用が少なく、治療効果が高い究極の分子標的薬として注目されているが、細胞膜透過性が低いという欠点があり、効率のよいドラッグデリバリーシステム (DDS) の開発が求められていた。本研究では、我々が発見した膜透過促進ペプチドを利用して、抗体/ペプチド/核酸を従来よりも効率よく細胞質に送達できることを示した。また、基礎研究として、その膜透過促進メカニズムの解明も並行して進めた。
Biopharmaceuticals consisting of antibodies, peptides or nucleic acids, which have high specificity and affinity for target molecules, are attracting attention as the ultimate molecular targeted drugs with less side effects and higher therapeutic effects than conventional drugs consisting of low-molecular compounds. However, biopharmaceuticals have a drawback of low cell membrane permeability, and thus development of an efficient drug delivery system (DDS) for biopharmaceuticals has been required. In this study, we discovered a membrane penetration-enhancing peptide for efficient cytoplasmic delivery of antibodies, peptides, and nucleic acids. In addition, as a basic research, we analyzed the membrane permeation mechanism.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2017~2019
課題番号 : 17H02103
研究分野 : 分子生物学
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Mar 5, 2021 | | インデックス を変更 |
Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Creator 著者ID,Abstract 内容,Note 注記 を変更 |
Apr 11, 2024 | | Creator を変更 |
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