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KAKEN_17H01562seika.pdf
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Title |
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エネルギー代謝維持多臓器間サーキットのハブ臓器としての腎臓の意義と代謝性腎症
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エネルギー タイシャ イジ タゾウキカン サーキット ノ ハブ ゾウキ ト シテ ノ ジンゾウ ノ イギ ト タイシャセイ ジンショウ
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Enerugī taisha iji tazōkikan sākitto no habu zōki to shite no jinzō no igi to taishasei jinshō
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The significant role of the kidney as a central organ for metabolic organ interrelationship
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伊藤, 裕
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イトウ, ヒロシ
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Romanization |
Itō, Hiroshi
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 40252457
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長谷川, 一宏
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ハセガワ, カズヒロ
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Romanization |
Hasegawa, Kazuhiro
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 30424162
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脇野, 修
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ワキノ, シュウ
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Wakino, Shū
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慶應義塾大学・医学部 (信濃町) ・准教授
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Research team member
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科研費研究者番号 : 50265823
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徳山, 博文
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トクヤマ, ヒロブミ
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Tokuyama, Hirobumi
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 50276250
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神田, 武志
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カンダ, タケシ
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Kanda, Takeshi
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 80317114
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2020
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科学研究費補助金研究成果報告書
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2019
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糖尿病性腎症を始めとする代謝異常に基づくCKDをMKD (Metabolic Kidney Disease) ととらえMKDにおいては、心蔵、肝臓、脂肪組織、腸管に機能・構造的障害が続発的に発症し、全身のエネルギー代謝の障害を引き起こす。MKDでのSGLT2の発現調節、肝臓由来のケトン体の意義、腸内環境の偏倚によるインスリン抵抗性の発症などを解明した。更にMKDによるエネルギー代謝障害が、MKDの病態をさらに加速する。特にNAD代謝異常が腎線維化に及ぼす影響を明らかにした。これらの成果を用いた新規治療の開発も行い、グレリンの腎不全に対する臨床応用、NAD前駆体NMNの臨床応用を進めている。
We propose the concept of "Metabolic Kidney Diseases (MKD)", which is the chronic kidney dysfunction induced by renal metabolic alterations. MKD includes diabetic nephropathy, nephrosclerosis and obesity-related glomerulopathy. In the context of MKD, the kidney can act as the integral organ for energy metabolism. As for kidney-adipose tissue-liver-muscle axis, we elucidated that MKD induces insulin resistance caused by the excessive uremic toxins produced by gut microbiota and translocation to systemic circulation (kidney-gut axis). These metabolic alterations in turn affects the renal structure and function. Nutrients, such as glucose, NAD metabolites or ketone bodies act as signaling molecules to modulate renal functions, such as the expression of SGLT2, ischemia response, or fibrosis. We focused on these abnormalities as therapeutic targets and attempted clinical trials, such as the administrations of ghrelin or NMN into humans for treatment of MKD-associated diseases.
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研究種目 : 基盤研究 (A) (一般)
研究期間 : 2017~2019
課題番号 : 17H01562
研究分野 : 腎臓病学, 内分泌学
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Mar 5, 2021 | | インデックス を変更 |
Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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