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KAKEN_16K15183seika.pdf
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Download
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:196.6 KB
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:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 425
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シナプス機能および記憶学習を制御する細胞接着型GPCRの新しい活動機構
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シナプス キノウ オヨビ キオク ガクシュウ オ セイギョスル サイボウ セッチャクガタ GPCR ノ アタラシイ カツドウ キコウ
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Shinapusu kinō oyobi kioku gakushū o seigyosuru saibō setchakugata GPCR no atarashii katsudō kikō
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A novel role of adhesion-GPCR in synaptic functions and motor learning.
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掛川, 渉
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カケガワ, ワタル
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Kakegawa, Wataru
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慶應義塾大学・医学部(信濃町)・准教授
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Research team head
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科研費研究者番号 : 70383718
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柚﨑, 通介
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ユザキ, ミチスケ
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Yuzaki, Michisuke
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慶應義塾大学・医学部(信濃町)・教授
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Research team member
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科研費研究者番号 : 40365226
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三浦, 会里子
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ミウラ, エリコ
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Miura, Eriko
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慶應義塾大学・医学部(信濃町)・研究員
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Research team member
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科研費研究者番号 : 10571169
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本橋, 淳子
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モトハシ, ジュンコ
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Motohashi, Junko
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慶應義塾大学・医学部(信濃町)・研究員
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Research team member
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科研費研究者番号 : 10407083
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
近年, 記憶・学習を担う「シナプス」を制御する分子として, 細胞接着型Gタンパク共役受容体(adhesion-GPCR; ADGR)が注目されている。ADGRは種々の機能ドメインを有する細胞外領域と, GPCRに共通な７回膜貫通部位およびGタンパクと結合する細胞内領域からなるユニークな分子であるが, シナプスでどのように働いているかは不明な点が多い。本研究では, ADGRメンバーのBAI3が, 運動記憶を担う小脳のプルキンエ細胞に発現し, 延髄下オリーブ核登上線維(climbing fiber; CF)間で形成されるCFシナプスの形態・機能に重要であることを明らかにし, その活動様式を追究した。
Recently, adhesion-type G protein-coupled receptors (ADGRs) have been intensively studied as molecules which regulate synapse integrity and learning & memory in the CNS. ADGR has a unique structure which contains an extracellular N-terminal domain with various types of functional domains, a seven-transmembrane region and an intracellular domain interacting with several signal molecules including G proteins. Despite its unique structure, the mechanisms by which ADGR behaves at synapses have remained unclear. In this study, we demonstrated that a brain-specific angiogenesis inhibitor 3 (BAI3), an ADGR member abundantly expressed at the synapses between climbing fiber (CF) and Purkinje cell in the cerebellum, plays crucial roles in synapse morphology, synaptic plasticity and cerebellar motor learning.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2016～2017
課題番号 : 16K15183
研究分野 : 神経生理学
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