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KAKEN_16K10473seika.pdf
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Title |
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乳がん組織の複雑さによって生じるがん細胞協調メカニズムの解明
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Kana |
ニュウガン ソシキ ノ フクザツサ ニ ヨッテ ショウジル ガン サイボウ キョウチョウ メカニズム ノ カイメイ
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Nyūgan soshiki no fukuzatsusa ni yotte shōjiru gan saibō kyōchō mekanizumu no kaimei
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Cancer cell interaction mechanisms caused by the complexity of breast cancer tissues
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有馬, 好美
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アリマ, ヨシミ
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Arima, Yoshimi
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慶應義塾大学・医学部 (信濃町)・専任講師
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Research team head
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科研費研究者番号 : 20309751
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2019
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科学研究費補助金研究成果報告書
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2018
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がんは、ゲノム的にも形質的にも多様で、異なる性質を持つ不均一ながん細胞の集団およびそれらの微小環境で構成される複雑な組織である。ヒト由来の異なる2種類のトリプルネガティブ乳がん細胞株を混合して免疫不全マウスの乳腺組織に移植すると不均一ながん組織が形成され、1種類のヒトトリプ ルネガティブ乳がん細胞株を用いた時と比べて、より大きな腫瘍となることがわかった。RNA-seq解析を行い、この不均一ながん組織において、特徴的に発現する遺伝子群を見出した。見出した遺伝子群は腫瘍の増殖能に関与し、これらが乳がんの悪性度および治療抵抗性と関連する腫瘍内不均一性のバイオマーカーとなる可能性が考えられた。
Cancer is genomically and phenotypically diverse and composed of complex tissues, including tumor microenvironments and a heterogeneous population of cancer cells, all showing different characteristics. We formed heterogeneous cancer tissues by mixing two different human-derived triple-negative breast cancer cell lines and inoculating them into the mammary fat pads of immunodeficient mice. These heterogeneous cancers were more proliferative than the homogeneous cancers that were formed by individually inoculating the cell lines. We performed RNA-sequencing analysis to identify the genes which characteristically expressed in heterogeneous cancer tissues. Our hallmark genes seem to be involved in tumor growth and could be important biomarkers of intratumoral heterogeneity associated with malignancy and therapeutic resistance of breast cancers.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2016~2018
課題番号 : 16K10473
研究分野 : 腫瘍生物学
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