本研究は、計34家族、78名の被験者から頭部MRIデータを取得した。具体的はうつ病既往のある寛解状態の両親とその健康な子供をリクルート し、11の母娘ペア、12の母息子ペア、11の父娘ペア、10の父息子ペアの4つの性別の異なる親子ペアに分別をした。まず、それぞれの親子ペア内で灰白質の体積の相関を行い、default mode network (DMN)とcentral executive network (CEN)内に位置する前部帯状回、後部帯状回、中前頭回、上頭頂小葉、角 回、中側頭回にて、母と娘のペアにおいて有意な正の相関をみとめた。しかし、他の親子ペアでは体積の相関は一切認めなかった。
Parents have significant genetic and environmental influences, which are known as intergenerational effects, on the cognition, behavior, and brain of their offspring. The main purpose of our study was to investigate female-specific intergenerational transmission patterns in the human brain in patients with depression. We recruited 78 participants from 34 families, which included remitted parents with a history of depression and their healthy biological offspring who were at high risk of developing depression. Using independent component analysis, we found a significant positive correlation of gray matter between exclusively the mother-daughter dyads within brain regions located in the default mode and central executive networks. The current study provides novel biological evidence for greater vulnerability of daughters, but not sons, in developing depression whose mothers have a history of depression.

研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2020
課題番号 : 16K10224
研究分野 : うつ病の脳画像研究