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KAKEN_16K09327seika.pdf
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Download
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:77.9 KB
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:May 1, 2020 |
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Total downloads since May 1, 2020 : 470
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| Title |
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小腸粘膜防御因子DAOの腸内細菌と宿主による制御機構の解明
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ショウチョウ ネンマク ボウギョ インシ DAO ノ チョウナイ サイキン ト シュクシュ ニ ヨル セイギョ キコウ ノ カイメイ
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Shōchō nenmaku bōgyo inshi DAO no chōnai saikin to shukushu ni yoru seigyo kikō no kaimei
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Host-microbe interaction through innate immune factor DAO
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笹部, 潤平
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ササベ, ジュンペイ
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Sasabe, Jumpei
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 10398612
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鈴木, 将貴
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スズキ, マサタカ
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Suzuki, Masataka
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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本研究では、小腸の粘膜防御因子であるD-アミノ酸酸化酵素DAOの制御機構、およびDAOによる宿主免疫調節機構について明らかにした。DAOは腸内細菌叢によって誘導され、MyD88やRIPK2などの一般的なパターン認識受容体の下流分子は誘導には関与しないことを見出した。また、DAOは細菌のD-アミノ酸を代謝することにより、(１) DAO感受性細菌によるT細胞依存的な獲得免疫系の賦活化、(２) 細菌性D-アミノ酸によるT細胞非依存的な獲得免疫系の容量増加、の２種類のメカニズムで宿主免疫の調節を行っていることを明らかにした。
We investigated expressional regulation of the mucosal innate defense factor D-amino acid oxidase, DAO, and immune modulation by DAO in mammals. We have shown that DAO expression was induced by commensal microbiota through non-canonical pathway that does not involve canonical signaling molecules, MyD88 or RIPK2. We have also found that D-amino acid metabolism by DAO regulates adaptive immune system: (1) activation of immune responses through T-cell dependent signals triggered by DAO-sensitive microbiota, and (2) increase capacity of the responses through T-cell independent signals.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2018
課題番号 : 16K09327
研究分野 : 腸内細菌
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| Oct 31, 2019 | | インデックス を変更 |
| May 1, 2020 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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