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KAKEN_16K08506seika.pdf
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Download
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:291.6 KB
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:Oct 31, 2019 |
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Total downloads since Oct 31, 2019 : 460
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骨吸収窩糖タンパク質が誘導する新規骨形成制御機構の解明
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コツキュウシュウカ トウタンパクシツ ガ ユウドウスル シンキ コツケイセイ セイギョ キコウ ノ カイメイ
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Kotsukyūshūka tōtanpakushitsu ga yūdōsuru shinki kotsukeisei seigyo kikō no kaimei
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Identification of the glycoproteins-induced bone formation mechanisms at bone resorption lacunae
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黒田, 有希子
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クロダ, ユキコ
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Kuroda, Yukiko
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 70455343
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2019
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科学研究費補助金研究成果報告書
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2018
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骨吸収窩に豊富に存在する糖タンパク質の生理的役割はあまりよくわかっていない。軟骨が骨に置き換わる内軟骨性骨化過程では、マトリックスプロテアーゼMMP-9の局在が、糖鎖修飾の有無により大きく異なっていた。軟骨が骨に置き換わる血管侵入部位ではシアル酸修飾されていないMMP-9が、破骨細胞内や骨形成能を持つ骨芽細胞が集積している吸収窩ではシアル酸修飾を受けたMMP-9が発現していた。以上の結果より、シアル酸修飾されていないMMP-9は血管内皮細胞を誘引し、シアル酸修飾されたMMP-9は骨芽細胞の集積と骨形成を誘導していることが強く示唆された。
Abundant glycoproteins exist in bone resorption lacunae, whereas their physiological roles remain unknown. During endochondral ossification, localization of matrix metalloproteinase-9 (MMP-9) was significantly different according to its glycosylation state.
Non-glycosylated MMP-9 is exclusively present around tips of capillary vessels in the chondro-osseous junction. On the other hand, sialylated MMP-9 exists in osteoclasts and resorption lacunae accompanied with mature osteoblasts. These results suggest that non-glycosylated MMP-9 attracts endothelial cells, while sialylated MMP-9 enhances the osteoblast migration and bone formation at bone resorption lacunae.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2018
課題番号 : 16K08506
研究分野 : 骨生物学
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