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KAKEN_16H05249seika.pdf
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Title |
Title |
脂質異常症の質的な評価と動脈硬化性疾患の関連についての地域疫学研究
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Kana |
シシツ イジョウショウ ノ シツテキナ ヒョウカ ト ドウミャク コウカセイ シッカン ノ カンレン ニ ツイテ ノ チイキ エキガク ケンキュウ
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Shishitsu ijōshō no shitsutekina hyōka to dōmyaku kōkasei shikkan no kanren ni tsuite no chiiki ekigaku kenkyū
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Assessment of quality of lipid parameters as a novel risk factor for cardiovascular diseases in community-based epidemiologic studies
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岡村, 智教
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Kana |
オカムラ, トモノリ
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Romanization |
Okamura, Tomonori
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Affiliation |
慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 00324567
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東山, 綾
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Kana |
ヒガシヤマ, アヤ
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Romanization |
Higashiyama, Aya
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Affiliation |
国立研究開発法人国立循環器病研究センター・病院・医長
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Research team member
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科研費研究者番号 : 20533003
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沢村, 達也
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サワムラ, タツヤ
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Sawamura, Tatsuya
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信州大学・学術研究院医学系・教授
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Research team member
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科研費研究者番号 : 30243033
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武林, 亨
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タケバヤシ, トオル
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Romanization |
Takebayashi, Tōru
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Affiliation |
慶應義塾大学・医学部 (信濃町) ・教授
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Research team member
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科研費研究者番号 : 30265780
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大久保, 孝義
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オオクボ, タカヨシ
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Romanization |
Ōkubo, Takayoshi
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帝京大学・医学部・教授
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Research team member
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科研費研究者番号 : 60344652
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2021
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科学研究費補助金研究成果報告書
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2020
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Abstract |
変性HDLを血中ApoA1含有LOX-1リガンドで評価した。喫煙は変性HDLを増加させるが、飲酒や運動習慣の影響はほとんど受けないこと、変性HDLは、糖尿病や高血圧などの交絡要因を調整しても冠動脈石灰化や動脈硬化性疾患(冠動脈疾患とアテローム血栓性梗塞)の発症と関連することが明らかとなった。しかし変性HDLは大動脈弾性機能の指標であるCAVI(Cardio Ankle Vascular Index)とは関連せず、また高齢層の冠動脈石灰化やラクナ梗塞とも関連しなかった。また今回検討したコホート内症例対照研究での動脈硬化性疾患の検討は追跡期間が短いため、追跡期間を延長した研究が今後必要である。
We have developed a novel ELISA by using recombinant LOX-1 and anti-apoA1 antibody to measure the activity of modified HDL(LOX-1 ligand containing apoA1, LAA). We selected 910 community-dwelling Japanese men aged 40-79 years and the multivariable adjusted odds ratio (95% confidence interval) per 1SD (standard deviation) of LAA for CAC (coronary artery calcification) was 1.14 (0.96-1.36) for all participants. Multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged under 65 and 65 years and greater, respectively. Furthermore, we conducted a nested case-control study from a rural cohort study including 52 new incidences of atherosclerotic cardiovascular disease and 156 by matching with baseline year, sex age, and health check-up facility. In multivariable analysis, the matched odd ratio for the highest vs. lowest quartiles of LAA was 2.50 (0.70-8.86) and that for 1SD increment of LAA was 2.16 (1.28-3.64).
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2016~2019
課題番号 : 16H05249
研究分野 : 疫学・公衆衛生学
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May 17, 2022 | | インデックス を変更 |
Nov 4, 2022 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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