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KAKEN_16H05083seika.pdf
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Title |
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細胞治療・バイオ創薬のための高機能分離精製技術の開発
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サイボウ チリョウ・バイオ ソウヤク ノ タメ ノ コウキノウ ブンリ セイセイ ギジュツ ノ カイハツ
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Saibō chiryō baio sōyaku no tame no kōkinō bunri seisei gijutsu no kaihatsu
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Development of high performance separation and purification technology for cell therapy and biopharmaceuticals
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金澤, 秀子
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カナザワ, ヒデコ
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Kanazawa, Hideko
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慶應義塾大学・薬学部 (芝共立) ・教授
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Research team head
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科研費研究者番号 : 10240996
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綾野, 絵理
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アヤノ, エリ
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Ayano, Eri
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慶應義塾大学・薬学部 (芝共立) ・研究員
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Research team member
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科研費研究者番号 : 10424102
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2019
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科学研究費補助金研究成果報告書
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2018
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近年、創薬・医療は、小分子薬からバイオ医薬品、遺伝子、細胞療法、再生医療へと変化しており、医療におけるこれらの変化に対応する新しい分離精製技術が求められている。細胞治療・再生医療の実用化には、治療に用いられるiPS 細胞や幹細胞由来の特定細胞の効率的な分離の技術の開発が不可欠であり、バイオ医薬品製造コストの削減のためにも極めて重要である。本研究では、申請者らが開発した刺激応答性高分子を用いた新しい概念の分離システムを基盤とし、治療に必要な細胞の特性を保持したまま分離する技術、選択的細胞クロマトグラフィーシステム及びバイオ創薬のための抗体医薬分離精製システムを開発した。
In recent years, the trends of drug discovery and medical care have changed, from small molecule drugs to biopharmaceuticals, genes, cell therapy, and regenerative medicine. New approaches and technologies need to be developed to respond to these changes in medical care. The development of a novel purification method for proteins, such as antibodies, under mildconditions is strongly needed. Cell separation method without modification of cell surfaces is strongly demanded for cell transplantation.
In this study, we developed temperature-responsive separation system to purify a antibody drug and cells.The prepared column would be applicable to various types of protein and cell separation applications by optimizing the properties of modified polymers. Therefore, the developed temperature-responsive column has the potential to be an effective protein and cell separation tool for biomedical applications.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2016~2018
課題番号 : 16H05083
研究分野 : 分離分析
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