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KAKEN_15KT0081seika.pdf
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Title |
Title |
形と流動性の再現から読み解く生命システムの秩序原理
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カタチ ト リュウドウセイ ノ サイゲン カラ ヨミトク セイメイ システム ノ チツジョ ゲンリ
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Katachi to ryūdōsei no saigen kara yomitoku seimei shisutemu no chitsujo genri
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Order principle of living cell homeostasis depicted by mimicking shape and fluidity of cells
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藤原, 慶
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フジワラ, ケイ
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Fujiwara, Kei
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慶應義塾大学・理工学部(矢上)・講師
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Research team head
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科研費研究者番号 : 20580989
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柳澤, 実穂
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ヤナギサワ, ミホ
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Yanagisawa, Miho
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東京大学・大学院総合文化研究科・准教授
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Research team member
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科研費研究者番号 : 50555802
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2019
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科学研究費補助金研究成果報告書
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2018
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本研究では、人工的に構成した細胞 (人工細胞) に、生命で機能する部品のグループを導入することで生じる物理的・化学的な変化を、「流動性・生命機能・空間形状」という3つのキーワードを軸に追求しました。結果、細胞が示す空間形状が内部の物質の移動や生命機能に与える影響や、流動性が生命機能の発現を変化させる仕組み、流動性が空間形状変化を制御する可能性など、通常の生命科学ではアクセスしづらい現象の発見やメカニズムの解明に至りました。また、生命機能の模倣による形状の安定化や、硬い生体適合ゲル合成など、研究成果が材料科学にも結び付くことを実証しました。
In this research, we investigated the physical and chemical changes caused by introducing a group of components that function in life into artificially constructed cells (artificial cell), based on the 3 physicochemical parameters: Function, Fluidity, and Spatial shapes". As a result, we have discovered phenomena that are difficult to access in ordinary biochemistry and molecular biology, such as the effects of boundaries of cells on the movement of molecules and its biological functions, the mechanism which fluidity changes the expression of biological functions, and the possibility that fluidity controls deformation of spatial shape. We also demonstrated that our research results are able to be applied to material science by creating DNA cytoskeleton to stabilize artificial cells and stiff biocompatible gels.
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研究種目 : 基盤研究 (B) (特設分野研究)
研究期間 : 2015~2018
課題番号 : 15KT0081
研究分野 : 合成生物学
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