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KAKEN_15K20323seika.pdf
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Download
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:1.5 MB
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 1578
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| Title |
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ホールマウント染色による胎仔皮膚創傷治癒組織の解析
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ホールマウント センショク ニ ヨル タイシ ヒフ ソウショウ チユ ソシキ ノ カイセキ
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Horumaunto senshoku ni yoru taishi hifu sosho chiyu soshiki no kaiseki
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Visualizing fetal skin wound tissue by whole-mount immunohistochemistry.
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崎尾, 怜子
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サキオ, レイコ
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Sakio, Reiko
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 70723261
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貴志, 和生
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キシ, カズオ
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Kishi, Kazuo
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Research team member
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2017
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科学研究費補助金研究成果報告書
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2016
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胎生期の無瘢痕性創傷治癒のメカニズムを探るために, ホールマウント染色標本を用いて創傷治癒組織の解析を行った。胎生13.5日目に作成した皮膚創傷組織を24時間後に回収して観察したところ, 創部中心に向かって盛んに血管新生が行われている様子を捉えることができたが, 胎生15.5日目以降になると, 有意にその血管新生は減少していた。また, 胎生13.5日目の創部には小型のマクロファージが表面を覆うように多数存在していたが, 胎生15.5日目以降の創部ではほとんど認められなかった。同細胞が血管新生と皮膚の再生に関与している可能性が考えられた。
To explore the mechanism of scarless wound healing, fetal skin wounds were created and analyzed using whole-mount immunohistochemistry. In the wound tissue of E13.5 embryos, numerous endothelial cells were observed extending their filopodia towards the center of the wounds, whereas after E15.5 seldom endothelial cells were observed in the superficial layer of the wounds. The surface of E13.5 wounds were covered with numerous macrophages, which were no longer observed after E15.5. These features may be related to the potential of skin wound to heal without scarring. Further morphological analysis in conjunction with genetic modification of animals will elucidate new insights into the mechanism of skin wound healing.
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研究種目 : 若手研究(B)
研究期間 : 2015～2016
課題番号 : 15K20323
研究分野 : 形成外科学
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