Item Type |
Article |
ID |
|
Preview |
Image |
|
Caption |
|
|
Full text |
KAKEN_15K19702seika.pdf
Type |
:application/pdf |
Download
|
Size |
:516.1 KB
|
Last updated |
:Aug 28, 2023 |
Downloads |
: 431 |
Total downloads since Aug 28, 2023 : 431
|
|
Release Date |
|
Title |
Title |
皮膚在住B細胞の生理学的機能解明
|
Kana |
ヒフ ザイジュウ Bサイボウ ノ セイリガクテキ キノウ カイメイ
|
Romanization |
Hifu zaiju Bsaibo no seirigakuteki kino kaimei
|
|
Other Title |
Title |
Physiological analysis of skin-resident B cells
|
Kana |
|
Romanization |
|
|
Creator |
Name |
足立, 剛也
|
Kana |
アダチ, タケヤ
|
Romanization |
Adachi, Takeya
|
Affiliation |
慶應義塾大学・医学部・助教
|
Affiliation (Translated) |
|
Role |
Research team head
|
Link |
科研費研究者番号 : 30573258
|
|
Edition |
|
Place |
|
Publisher |
|
Date |
Issued (from:yyyy) |
2017
|
Issued (to:yyyy) |
|
Created (yyyy-mm-dd) |
|
Updated (yyyy-mm-dd) |
|
Captured (yyyy-mm-dd) |
|
|
Physical description |
|
Source Title |
Name |
科学研究費補助金研究成果報告書
|
Name (Translated) |
|
Volume |
|
Issue |
|
Year |
2016
|
Month |
|
Start page |
|
End page |
|
|
ISSN |
|
ISBN |
|
DOI |
|
URI |
|
JaLCDOI |
|
NII Article ID |
|
Ichushi ID |
|
Other ID |
|
Doctoral dissertation |
Dissertation Number |
|
Date of granted |
|
Degree name |
|
Degree grantor |
|
|
Abstract |
皮膚を含む体表面のバリア臓器には様々な免疫細胞が存在し外的因子に対する宿主防御を司る。過剰な反応の抑制等, 免疫恒常性の維持にはこれら皮膚在住白血球を制御する緻密なメカニズムが存在するはずだが, 十分に解明されていなかった。本研究では, 皮膚常在メモリーT細胞が悪性化した際の表皮向性に毛嚢上皮細胞由来のサイトトカインが重要であることを解明するとともに, 皮膚在住B細胞についてもその特徴等解析を行った。これら病的状態および定常状態における皮膚在住メモリー型リンパ球の理解は, 複雑に絡み合った皮膚免疫機構の解明に寄与すると考えられる。
Barrier tissues including skin harbors a variety of resident leukocyte subsets to exert immune responses against external stimuli. They must be tightly regulated to maintain immunological homeostasis, which mechanisms have not been elucidated. In this study, we established a murine model recapitulating the cutaneous T cell lymphoma epidermotropism, which depended on the presence of hair follicle-derived cytokine. These results in pathological-state as well as the characterization of skin-resident memory B cells in steady-state, would contribute to the fundamental recognition of complex immune systems in skin.
|
|
Table of contents |
|
Keyword |
|
NDC |
|
Note |
研究種目 : 若手研究(B)
研究期間 : 2015~2016
課題番号 : 15K19702
研究分野 : 皮膚免疫学・アレルギー学
|
|
Language |
|
Type of resource |
|
Genre |
|
Text version |
|
Related DOI |
|
Access conditions |
|
Last modified date |
|
Creation date |
|
Registerd by |
|
History |
Aug 28, 2023 | | Creator,Abstract 内容,Note 注記 を変更 |
|
|
Index |
|
Related to |
|