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KAKEN_15K19429seika.pdf
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Download
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:141.8 KB
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 244
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| Title |
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肺癌におけるFGF9の役割の解明
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| Kana |
ハイガン ニ オケル FGF9 ノ ヤクワリ ノ カイメイ
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Haigan ni okeru FGF9 no yakuwari no kaimei
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FGF9 is an important factor in lung cancer
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扇野, 圭子
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オウギノ, ケイコ
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Ogino, Keiko
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| Affiliation |
慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 40573324
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2017
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科学研究費補助金研究成果報告書
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2016
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近年, FGFを含む各種増殖因子が癌の生物学において重要であることが報告されており, 我々はFGF9に注目し肺癌におけるFGF9の役割について研究を行った。FGF9を発現していない肺上皮細胞株及び肺癌株にFGF9遺伝子を導入しFGF9過剰発現細胞を作製した。非小細胞肺癌(肺腺癌)の細胞株であるA549にFGF9を過剰発現させたところFGF9過剰発現細胞株で足場非依存性の増殖能を獲得したことを確認した。FGF9を高発現した2型肺胞上皮細胞株MLE12-FGF9では免疫不全マウスに皮下移植したところ, 小細胞癌を形成し, FGF9は肺小細胞癌においてもoncogeneとしての働きがある可能性が考えられた。
In recent years, it has been reported that various growth factors including FGF are important in biology of cancer, and we focus on FGF 9 and investigated the role of FGF 9 in lung cancer. FGF9 gene was introduced into lung epithelial cell line and lung cancer cell line not expressing FGF9 to prepare FGF9 overexpressing cells. Overexpression of FGF9 in A549, a cell line of non small cell lung cancer (lung adenocarcinoma), confirmed that it acquired anchorage independent growth ability in FGF9 overexpressing cell line. In the type 2 alveolar epithelial cell line MLE12-FGF9 highly expressing FGF9, subcutaneous transplantation into immunodeficient mice forms small cell carcinoma and it is thought that FGF9 may act as oncogene in lung small cell carcinoma.
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研究種目 : 若手研究(B)
研究期間 : 2015～2016
課題番号 : 15K19429
研究分野 : 呼吸器腫瘍
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