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KAKEN_15K14398seika.pdf
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Download
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:425.3 KB
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:Aug 2, 2019 |
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Total downloads since Aug 2, 2019 : 216
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Imaging Mass-spectrometryの癌領域での臨床応用へ向けて
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Imaging Mass-spectrometry ノ ガン リョウイキ デノ リンショウ オウヨウ エ ムケテ
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Imaging Mass-spectrometry no gan ryoiki deno rinsho oyo e mukete
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Clinical application of Imaging Mass-spectrometry in cancer field
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安田, 浩之
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ヤスダ, ヒロユキ
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Yasuda, Hiroyuki
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慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 70365261
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2017
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科学研究費補助金研究成果報告書
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2016
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癌患者の予後は依然不良で, その改善のためには多方面から癌医療を改善する必要がある。Imaging Mass-spectrometry(MS)は, 組織切片内の各局在部位(ピクセル)での標的分子を質量分析器を用いて網羅的に定量し, それを「可視化」することができる最新の工学的technologyです。本研究の中で我々は, 血管新生阻害薬が癌細胞にどのような影響を与えるかを明らかにしました。Imaging MSを用いて抗癌剤がどのように効果を発揮するかを明らかにすることで, 抗癌剤の効率的な使用方法の確立につながる可能性があると考えている。
The prognosis of cancer patients is poor. To improve the prognosis of cancer patients, variable approaches are necessary. Imaging mass-spectrometry (IMS) is a novel technology, which enables one to viisualize the distribution of hundreds of metabloite in tissues. Using this novel technology, we treid to clarify the mechansims of efficacy of some anti-cancer agents. We focused on anti-angiogenic agents such as nintedanib or bevacizumab. We partly clarified the mechanisms of efficacy of these agents by in vivo experiments with IMS. The findings will help developing an effective and appropriate treatement using anti-angiogenic agents.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2015～2016
課題番号 : 15K14398
研究分野 : 癌
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| Aug 2, 2019 | | 著者,抄録 内容,資源タイプ を変更 |
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