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KAKEN_15K10344seika.pdf
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Download
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:89.4 KB
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:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 206
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悪性神経膠腫および腫瘍新生血管に対する複合的ペプチドワクチン療法の評価法開発
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アクセイ シンケイ コウシュ オヨビ シュヨウ シンセイ ケッカン ニ タイスル フクゴウテキ ペプチド ワクチン リョウホウ ノ ヒョウカホウ カイハツ
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Akusei shinkei kōshu oyobi shuyō shinsei kekkan ni taisuru fukugōteki pepuchido wakuchin ryōhō no hyōkahō kaihatsu
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Biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines against malignant glioma patients
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植田, 良
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ウエダ, リョウ
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Ueda, Ryo
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慶應義塾大学・医学部・共同研究員
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Research team head
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科研費研究者番号 : 30317143
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戸田, 正博
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トダ, マサヒロ
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Toda, Masahiro
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慶應義塾大学・医学部・准教授
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Research team member
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科研費研究者番号 : 20217508
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2018
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科学研究費補助金研究成果報告書
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2017
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本研究では, 申請者らが併行して実施している悪性神経膠腫および腫瘍新生血管に対するペプチドワクチン療法臨床試験(計3試験)被験者検体を用いて, 免疫応答関連細胞・因子, また脳腫瘍血管新生および浸潤性関連因子について解析し, 臨床的有効性との関連性を検証した。その結果, 同ワクチン療法による臨床的有効性を認めた患者検体では, ワクチン療法後にVEGFR発現細胞反応性細胞傷害性T細胞の高頻度検出, 血清中のsVEGFR2値の低下, 血漿中のIL-8値の低下を認めており, これらは同ワクチン療法バイオマーカーとして治療効果評価や治療反応性予測に応用しうると考えられた。
Evaluation of immunological biomarkers may lead to better understanding of the critical immune response indicators that may help to predict clinical responses of cancer immunotherapy. We characterized status of immune cells, cytokines, chemokines, and other immunosuppressive molecules in malignant glioma patients who received vaccinations of VEGF receptor (VEGFR)-derived peptides. Peripheral blood samples from patients who demonstrated positive radiologic response or stable disease revealed superior VEGFR-specific CTL reactivity and lower level of serum VEGF compared to samples from other patients with progressing malignant glioma. Plasma IL-8 level was negatively correlated with overall survival. These data indicate that these parameters may be potential immune-biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K10344
研究分野 : 脳神経外科学
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