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KAKEN_15K10343seika.pdf
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Title |
Title |
神経膠腫における分子生物学的分類と個別化治療の確立
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Kana |
シンケイ コウシュ ニ オケル ブンシ セイブツガクテキ ブンルイ ト コベツカ チリョウ ノ カクリツ
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Romanization |
Shinkei kōshu ni okeru bunshi seibutsugakuteki bunrui to kobetsuka chiryō no kakuritsu
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Other Title |
Title |
Towards personalized treatment of diffuse gliomas based on molecular characteristics
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Creator |
Name |
佐々木, 光
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Kana |
ササキ, ヒカル
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Romanization |
Sasaki, Hikaru
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Affiliation |
慶應義塾大学・医学部(信濃町)・講師
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Affiliation (Translated) |
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Role |
Research team head
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Link |
科研費研究者番号 : 70245512
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Name |
廣瀬, 雄一
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Kana |
ヒロセ, ユウイチ
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Romanization |
Hirose, Yuichi
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Affiliation |
藤田保健衛生大学・医学部・教授
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Affiliation (Translated) |
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Role |
Research team member
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Link |
科研費研究者番号 : 60218849
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Name |
吉田, 一成
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Kana |
ヨシダ, カズナリ
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Romanization |
Yoshida, Kazunari
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Affiliation |
慶應義塾大学・医学部・教授
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Affiliation (Translated) |
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Research team member
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Link |
科研費研究者番号 : 70166940
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Name |
佐谷, 秀行
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Kana |
サヤ, ヒデユキ
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Romanization |
Saya, Hideyuki
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Affiliation |
慶應義塾大学・医学部・教授
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Affiliation (Translated) |
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Role |
Research team member
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Link |
科研費研究者番号 : 80264282
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Name |
尾原, 健太郎
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Kana |
オハラ, ケンタロウ
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Romanization |
Ohara, Kentaro
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Affiliation |
慶應義塾大学・医学部・助教
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Affiliation (Translated) |
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Role |
Research team member
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Link |
科研費研究者番号 : 40571724
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Name |
北村, 洋平
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Kana |
キタムラ, ヨウヘイ
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Romanization |
Kitamura, Yohei
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Affiliation |
済生会宇都宮病院脳神経外科, 現マサチューセッツ総合病院研究員
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Affiliation (Translated) |
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Role |
Research team member
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Link |
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Name |
林, 佐衣子
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Kana |
ハヤシ, サエコ
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Romanization |
Hayashi, Saeko
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Affiliation |
慶應義塾大学医学部大学院, 現永寿総合病院脳神経外科
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Affiliation (Translated) |
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Role |
Research team member
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Link |
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Name |
中川, 祐
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Kana |
ナカガワ, ユウ
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Romanization |
Nakagawa, Yu
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Affiliation |
慶應義塾大学医学部大学院, 現済生会東部病院脳神経外科
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Affiliation (Translated) |
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Research team member
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Link |
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Name |
釜本, 大
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Kana |
カマモト, ダイ
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Romanization |
Kamamoto, Dai
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Affiliation |
慶應義塾大学医学部大学院
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Affiliation (Translated) |
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Research team member
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Link |
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Name |
金澤, 徳典
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Kana |
カナザワ, トクノリ
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Romanization |
Kanazawa, Tokunori
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Affiliation |
慶應義塾大学医学部大学院
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Affiliation (Translated) |
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Research team member
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Link |
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Name |
Pareira, Eriel Sandika
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Kana |
パレーラ, エリル サンディカ
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Romanization |
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Affiliation |
慶應義塾大学医学部大学院
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Affiliation (Translated) |
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Research team member
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Link |
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Name |
津崎, 尚子
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Kana |
ツザキ, ナオコ
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Romanization |
Tsuzaki, Naoko
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Affiliation |
実験助手
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Affiliation (Translated) |
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Role |
Research team member
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Issued (from:yyyy) |
2018
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Source Title |
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科学研究費補助金研究成果報告書
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2017
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Abstract |
多くの神経膠腫は未だに根治困難であり, さらなる分子分類と治療の最適化が必要である。我々は, 術前化学療法(neoadjuvant chemotherapy)戦略の神経膠腫における有用性を検討し, 1p/19q codelやMGMTメチル化 をもつ神経膠腫に対しては, 化学療法による腫瘍縮小後のsecond-look resectionにより予後が改善される可能性を示し, また術前画像所見の組み合わせから, 分子マーカーを予測するスコアシステムを開発した。さらに, ロゼット形成性グリア神経細胞腫瘍の遺伝学的背景及び1p/19q codel神経膠腫の予後や膠芽腫長期生存に関わる因子を明らかにした。
The majority of diffuse gliomas is not curable yet, and the development of the personalized treatments according to molecular characteristics is indispensable. The main aims of this study were to establish the personalized therapies and to explore the utility of the neoadjuvant chemotherapy for chemo-sensitive gliomas. The prospective study for the diffuse gliomas with 1p/19q codeletion or MGMT promoter methylation suggested that upfront chemotherapy and subsequent resection for initial incomplete resections might be superior to chemotherapy and observation strategy. To preoperatively design the neoadjuvant strategy, we established the scoring systems to predict 1p/19q codeletion and MGMT methylation based on imaging features. Moreover, we have elucidated the molecular background of the rosette-forming glioneuronal tumor, molecular-pathological prognostic factors in 1p/19q-codeleted gliomas, and the factors favorably associated with long-term survival in glioblastoma patients.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015~2017
課題番号 : 15K10343
研究分野 : 脳腫瘍
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