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KAKEN_15K09098seika.pdf
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Download
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:387.1 KB
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| Last updated |
:Apr 24, 2020 |
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: 638 |
Total downloads since Apr 24, 2020 : 638
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| Title |
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微小血管構造を有するヒトiPS細胞由来心筋球を用いた新しい細胞移植法の開発
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| Kana |
ビショウ ケッカン コウゾウ オ ユウスル ヒト iPS サイボウ ユライ シンキンキュウ オ モチイタ アタラシイ サイボウ イショクホウ ノ カイハツ
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Bishō kekkan kōzō o yūsuru hito iPS saibō yurai shinkinkyū o mochiita atarashii saibō ishokuhō no kaihatsu
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Development of novel cell transplantation method using cardiomyocytes derived from human iPS cells with microvessel structure
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カナザワ, ヒデアキ
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Kanazawa, Hideaki
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| Affiliation |
慶應義塾大学・医学部(信濃町)・講師
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Research team head
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科研費研究者番号 : 40338033
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フジタ, ジュン
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Fujita, Jun
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慶應義塾大学・医学部(信濃町)・特任准教授
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Research team member
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科研費研究者番号 : 10306706
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福田, 恵一
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フクダ, ケイイチ
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Fukuda, Keiichi
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慶應義塾大学・医学部(信濃町)・教授
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Research team member
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科研費研究者番号 : 20199227
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フクダ, ジュンジ
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Fukuda, Junji
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横浜国立大学・大学院工学研究院・准教授
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Research team member
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科研費研究者番号 : 80431675
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2018
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科学研究費補助金研究成果報告書
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2017
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酸素透過性のポリジメチルシロキサン(poly-dimethylsiloxane ; PDMS)膜を底面 とする特殊な培養器(PDMS培養器)を用いることによって, 心筋塊(スフェロイド)の作製が可能となった。これらの心筋細胞は, 成熟化マーカーであるmyosin light chain (MLY2)が高い傾向にあり, 心筋細胞が成熟化傾向にあった。一方, 酸素透過しない従来の培養器では, 低酸素誘導因子(HIF : Hypoxia-Inducible Factor)のtarget遺伝子発現が高い傾向が確認された。
By using a special incubator with an oxygen permeable poly-dimethylsiloxane (PDMS) membrane as the bottom surface, it was possible to product myocardial spheroids. These cardiomyocytes tended to have a high myosin light chain (MLY 2) which is a maturation marker. On the other hand, in the conventional incubator that does not permeate oxygen, the tendency of target gene expression of Hypoxia-Inducible Factor (HIF) was high.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K09098
研究分野 : 心筋再生
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| History |
| Nov 12, 2018 | | インデックス を変更 |
| Apr 24, 2020 | | Creator 著者ID,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Creator,Abstract 内容,Note 注記 を変更 |
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