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KAKEN_15K06719seika.pdf
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Download
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:432.0 KB
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:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 402
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グリア細胞の発生・分化機構の解明
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グリア サイボウ ノ ハッセイ・ブンカ キコウ ノ カイメイ
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Guria saibō no hassei bunka kikō no kaimei
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Mechanisms of glial development
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島崎, 琢也
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シマザキ, タクヤ
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Shimazaki, Takuya
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慶應義塾大学・医学部・准教授
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Research team head
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科研費研究者番号 : 00324749
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津山, 淳
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ツヤマ, ジュン
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Tsuyama, Jun
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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本研究はグリア前駆細胞, あるいは幹細胞がグリアへ分化する遷移状態を捉える方法の開発を目的として行われた。そして, 神経幹細胞発生における時系列特異的なグリア分化能変化に応じて変化する遺伝子発現の比較解析とin situ hybridizationによる発現解析により, グリア前駆細胞, もしくは神経幹細胞のグリアへの分化の指標となるマーカー遺伝子として, 内向き整流性K+チャネルの一種であるKcnj16を同定した。そして, この遺伝子発現のレポーター系が神経幹細胞がグリア前駆細胞へ分化していく遷移状態を捉えるのに有用であることが示唆された。
We attempted to develop a system to visualize glial-restricted progenitors (GRPs) and/or transition state of neural stem cell (NSC) differentiation into glia. We identified Kcnj16 which is an inward-rectifier type potassium channel as a marker for GRPs or glial differentiation of NSCs via expression profiling to identify genes which respond to the temporal changes of gliogenic potency of NSCs during development and in situ hybridization analysis of expression pattern of candidate genes during central nervous system development. Finally, it has been suggested that a reporter system which can recapitulate the expression pattern of Kcnj16 can be applicable to visualize GRPs or glial differentiation of NSCs.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K06719
研究分野 : 神経発生学
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