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KAKEN_15H06593seika.pdf
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Download
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:330.4 KB
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:Mar 18, 2022 |
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: 98 |
Total downloads since Mar 18, 2022 : 98
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新規薬剤LOTUSと歩行訓練併用療法による霊長類脊髄損傷からの二足歩行再建
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シンキ ヤクザイ LOTUS ト ホコウ クンレン ヘイヨウ リョウホウ ニ ヨル レイチョウルイ セキズイ ソンショウ カラ ノ ニソク ホコウ サイケン
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Shinki yakuzai LOTUS to hoko kunren heiyo ryoho ni yoru reichorui sekizui sonsho kara no nisoku hoko saiken
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Combining LOTUS and rehabilitation therapy after for restoration of locomotor function after spinal cord injury in primates
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近藤, 崇弘
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コンドウ, タカヒロ
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Kondo, Takahiro
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| Affiliation |
慶應義塾大学・医学部・特任助教
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Research team head
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科研費研究者番号 : 70759886
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2017
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科学研究費補助金研究成果報告書
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2016
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今回の研究では, 新規薬剤のLOTUSが皮質脊髄路を伸長させる可能性が示唆された。一方で, 小型霊長類においては重度脊髄損傷後に歩行リハビリが四足歩行機能を再建させ, さらにリハビリ群では皮質―脊髄間の機能的な神経接続が示唆されたものの, リハビリ単独では二足歩行の再建までには至らなかったことがわかった。今後は両者の治療法を組み合わせることで, 二足歩行を再建させることが重要であり, 現在併用療法を遂行中である。
In this study, it was suggested that LOTUS, a novel drug, could extend the corticospinal tract. On the other hand, in small primates, locomotor rehabilitation reconstructed the quadrupedal locomotion function after severe spinal cord injury, and functional neural connections between the cortex and the spinal cord were suggested in the rehabilitation group. However, it was found that bipedal walking does not recover only with rehabilitation treatment. In the future it is important to reconstruct bipedal locomotion by combining the therapies of both, and is currently undergoing combination therapy.
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研究種目 : 研究活動スタート支援
研究期間 : 2015～2016
課題番号 : 15H06593
研究分野 : 生理学
PDFファイルは改訂版に差し替え (2022.3.15)
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| Aug 1, 2019 | | 著者,抄録 内容,資源タイプ を変更 |
| Dec 21, 2020 | | Preview,Full text,Creator Romanization を変更 |
| Mar 15, 2022 | | Preview,Full text を変更 |
| Mar 18, 2022 | | Note 注記 を変更 |
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