| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_15H05772seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:318.1 KB
|
| Last updated |
:Mar 5, 2021 |
| Downloads |
: 317 |
Total downloads since Mar 5, 2021 : 317
|
|
| Release Date |
|
| Title |
| Title |
補体ファミリー分子によるシナプス形成・維持・除去と可塑性制御機構の解明
|
| Kana |
ホタイ ファミリー ブンシ ニ ヨル シナプス ケイセイ・イジ・ジョキョ ト カソセイ セイギョ キコウ ノ カイメイ
|
| Romanization |
Hotai famirī bunshi ni yoru shinapusu keisei iji jokyo to kasosei seigyo kikō no kaimei
|
|
| Other Title |
| Title |
Regulation of synapse formation, maintenance, elimination and plasticity by C1q family proteins
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
柚崎, 通介
 |
| Kana |
ユザキ, ミチスケ
|
| Romanization |
Yuzaki, Michisuke
|
| Affiliation |
慶應義塾大学・医学部 (信濃町) ・教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 40365226
|
| Name |
武内, 恒成
|
| Kana |
タケウチ, コウセイ
|
| Romanization |
Takeuchi, Kōsei
|
| Affiliation |
愛知医科大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 90206946
|
| Name |
|
| Kana |
|
| Romanization |
|
| Affiliation |
|
| Affiliation (Translated) |
|
| Role |
|
| Link |
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
脳の作動原理および精神･神経疾患の病態を理解するためには、神経回路の基盤をなすシナプスがどのように形成され、生涯にわたって改変されていくのかを解明することが必須である。本研究では、私たちが発見した新しいシナプス形成分子である補体ファミリー分子Cbln1およびC1qL1-3に焦点をあて、小脳・海馬の代表的な神経回路においてどのように分泌され、どのように機能するのかを明らかにすることに成功した。
Abnormal synaptic connections contribute to various neuropsychiatric, neurodevelopmental and neurological disorders, such as autism spectrum disorders, schizophrenia and Alzheimer's dementia. However, it has remained largely unclear how vast numbers of connections are precisely established, maintained, and modified throughout life. In this study, we addressed this question by focusing on a new class of synaptic organizers, C1q family proteins. We have demonstrated how Cbln1, C11L1-3 proteins are released and functions in representative neural circuits of the hippocampus and the cerebellum.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究 (S)
研究期間 : 2015～2019
課題番号 : 15H05772
研究分野 : 総合生物、神経科学、神経生理学・神経科学一般
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
