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KAKEN_15H05507seika.pdf
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:891.5 KB
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:Mar 5, 2021 |
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| Title |
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単一分子をトレーサとするナノチャネル時空間流動計測法の創成
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タンイツ ブンシ オ トレーサ ト スル ナノチャネル ジクウカン リュウドウ ケイソクホウ ノ ソウセイ
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Tan'itsu bunshi o torēsa to suru nanochaneru jikūkan ryūdō keisokuhō no sōsei
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Creation of spatially and temporally resolved flow measurement method for nanochannels utilizing single molecule as tracer
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嘉副, 裕
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カゾエ, ユタカ
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Kazoe, Yutaka
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慶應義塾大学・理工学部 (矢上) ・講師
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Research team head
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科研費研究者番号 : 20600919
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2020
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科学研究費補助金研究成果報告書
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2019
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様々な流体操作を微小化・集積化するマイクロ流体工学が急速に進展し、近年ではナノ流体工学へと展開している。本研究では、極小のナノ空間の流動現象を理解するために、流れの中の1分子の移動量から流速分布を計測する分子画像流速計 (MIV) を提案した。サイズが制御された高分子であるデンドリマーを蛍光修飾したトレーサ分子を開発し、これをナノ流路における圧力駆動流の計測に応用した。本手法と得られた知見は、ナノ空間の流れと物質輸送の理解に寄与すると期待される。
Microfluidics has rapidly developed to miniaturize and integrate various fluidic operations. Recently, it has been further downscaled to nanofluidics. In this study, in order to understand fluid flows in ultrasmall nanospaces, we proposed a measurement method of flow velocity distribution by tracing the motion of single-molecules in fluid flows, which we call molecular image velocimetry (MIV). A tracer molecule with controlled size was developed by fluorescence modification of dendrimer, and applied to measurements of pressure-driven flow in a nanochannel. The proposed method and obtained knowledge will contribute to understand fluid dynamics and molecular transport in nanospaces.
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研究種目 : 若手研究 (A)
研究期間 : 2015～2018
課題番号 : 15H05507
研究分野 : マイクロ・ナノ流体工学
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