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KAKEN_15H05290seika.pdf
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Download
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:Nov 12, 2018 |
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| Title |
| Title |
東南アジアに多い若年性心臓突然死 : その実態を調査する
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| Kana |
トウナンアジア ニ オオイ ジャクネンセイ シンゾウ トツゼンシ : ソノ ジッタイ オ チョウサスル
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Tōnanajia ni ōi jakunensei shinzō totsuzenshi : sono jittai o chōsasuru
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| Title |
Sudden cardiac death of young prevalent in Southeast Asia : survey and investigation
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藤田, 眞幸
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フジタ, マサキ
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Fujita, Masaki
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| Affiliation |
慶應義塾大学・医学部(信濃町)・教授
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Research team head
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科研費研究者番号 : 00211524
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中嶋, 克行
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| Kana |
ナカジマ, カツユキ
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| Romanization |
Nakajima, Katsuyuki
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| Affiliation |
女子栄養大学・栄養学研究所・客員教授
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Research team member
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科研費研究者番号 : 10444051
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大澤, 資樹
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オオサワ, モトキ
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Osawa, Motoki
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| Affiliation |
東海大学・医学部・教授
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Research team member
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科研費研究者番号 : 90213686
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岡島, 史和
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| Kana |
オカジマ, フミカズ
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Okajima, Fumikazu
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青森大学・薬学部・教授
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Research team member
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科研費研究者番号 : 30142748
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村上, 正巳
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ムラカミ, マサミ
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Murakami, Masami
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群馬大学・医学部・教授
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Research team member
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Sirisup, Nantana
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タイ・チュラロンコン大学・医学部・准教授
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Research team member
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Chutivongse, Panuwat
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タイ・チュラロンコン大学・医学部・講師(チュラロンコン王記念病院・院長補佐)
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Research team member
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Islam, Mohammed N.
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| Affiliation |
マレーシア・国立マラ工科大学・医学部・教授
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Research team member
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Myo Thaik Oo
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| Affiliation |
ヤンゴン第一医科大学・医学部・教授
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Research team member
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Min Thu
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| Affiliation |
ヤンゴン第一医科大学・医学部・講師
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Research team member
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Brugada, Ramon
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| Kana |
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| Affiliation |
スペイン・ジローナ大学心臓血管系疾患遺伝子研究所・教授
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
健康な青壮年が夜間就寝中に突然死する原因不明の病態であるポックリ病症候群は, 日本や東南アジアに多く, タイでは, Lai-Taiと呼ばれてきた。我々の現地での実態調査によって, タイ全土では, 年間1200～1800人程度がLai-Taiで死亡していると推計された。Lai-Tai事例について, 不整脈突然死をきたすBrugada症候群等に関係するSC5NA遺伝子解析をしたところ, 72%の事例で, 何らかのアミノ酸置換を伴う変異がみられ, その中には, Lai-Taiにのみみられるものもあった。これらについては, 今後機能解析を行う予定である。また, ミャンマーの訪問調査では, 類似の病態があるとの情報を得た。
Pokkuri Death Syndrome (PDS) is a sudden unexpected nocturnal death of unknown cause in mostly young males that has been reported in Japan and other South-Asian countries. We have been investigating Lai-Tai, similar to PDS, in Thailand with our counterpart. And from our study, we estimated that there is approximately 1200 to 1800 Lai-Tai death cases in the whole country. Genetic analysis of SC5NA, responsible for Brugada syndrome and other sudden arrhythmic death was performed in Lai-Tai cases. There were more than one amino acid substitutions in 72% of the Lai-Tai cases, and some mutations seemed to be peculiar to Lai-Tai, which need to be analyzed functionally. We also found similar cases in Myanmar in our collaboration study.
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研究種目 : 基盤研究(B)(海外学術調査)
研究期間 : 2015～2017
課題番号 : 15H05290
研究分野 : 法医病理学, 突然死, 客観的法医学的診断
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