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KAKEN_15H05009seika.pdf
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急性生体侵襲下における単球系細胞の機能解析と組織傷害関連物質 (DAMPs) の制御
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| Kana |
キュウセイ セイタイ シンシュウカ ニ オケル タンキュウケイ サイボウ ノ キノウ カイセキ ト ソシキ ショウガイ カンレン ブッシツ (DAMPs) ノ セイギョ
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Kyūsei seitai shinshūka ni okeru tankyūkei saibō no kinō kaiseki to soshiki shōgai kanren busshitsu (DAMPs) no seigyo
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Functional analysis of monocyte-lineage blood cells and control of damage-associated molecular patterns (DAMPs) under the whole-body responses to injury/illness
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並木, 淳
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ナミキ, ジュン
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Namiki, Jun
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慶應義塾大学・医学部 (信濃町) ・客員准教授
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Research team head
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科研費研究者番号 : 20189195
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鈴木, さゆり
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スズキ, サユリ
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Suzuki, Sayuri
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Collaborator
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林田, 敬
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ハヤシダ, ケイ
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Hayashida, Kei
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Collaborator
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渋沢, 崇行
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シブサワ, タカユキ
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Shibusawa, Takayuki
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多村, 知剛
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タムラ, トモヨシ
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Tamura, Tomoyoshi
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Collaborator
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石濱, 泰
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イシハマ, ヤスシ
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Ishihama, Yasushi
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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| Abstract |
重症外傷患者の末梢血単球で一過性のHLA-DR発現低下がみられ、外傷後の予後を悪化させる易感染性状態を反映した反応と考えられた。重症sepsis患者では単球の傷害を示すHistone H3のリン酸化が認められ、生体侵襲後の細胞崩壊の指標となり得ることが示唆された。
組織傷害関連物質 (DAMPs) が生体侵襲後に血中に遊離し、予後を悪化させることが知られている。Sepsis患者ではHMGB-1 とtotal Histone H3が病状悪化に関係し、鈍的肝損傷モデルマウスを用いた検討では特にtotal Histone H3がDAMPs制御のターゲットの一つになると考えられた。
Expression of HLA-DR temporary decreased in peripheral monocytes of patients with severe trauma, suggesting that a response reflecting the compensatory anti-inflammatory response syndrome that worsen the prognosis after trauma. Phosphorylation of Histone H3 was observed in monocytes of severe sepsis patients and may be an indicator for broken monocytes after the whole-body responses to injury/illness.
It is known that damage-associated molecular patterns (DAMPs) release into the bloodstream after the whole-body responses to injury/illness and worsen the prognosis. HMGB-1 and total Histone H3 related to poor prognosis in septic patients. Our study of liver injury model mice showed especially total Histone H3 may be a target molecule for control of DAMPs.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2015～2018
課題番号 : 15H05009
研究分野 : 救急医学
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| History |
| Oct 31, 2019 | | インデックス を変更 |
| Aug 28, 2023 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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